Fields »
ABOUT
HELP
BLOG
COL11A1

GENERAL INFORMATION

Gene name

 COL11A1

Gene description

 Collagen, type XI, alpha 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Group enriched (hypothalamus, testis, cerebral cortex, pituitary gland, caudate, hippocampus, skin)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hypothalamus, testis, cerebral cortex, pituitary gland, caudate, hippocampus, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 COL11A1 (HGNC Symbol)

Synonyms

 CO11A1, COLL6, STL2

Description

 Collagen, type XI, alpha 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]

Chromosome

 1

Cytoband

 p21.1

Chromosome location (bp)

 102876467 - 103108496

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000060718 (version 83.38)

Entrez gene

 1301

UniProt

 P12107 (UniProt - Evidence at protein level)

neXtProt

 NX_P12107

Antibodypedia

 COL11A1 antibodies

PROTEIN BROWSER
COL11A1-001
COL11A1-002
COL11A1-003
COL11A1-008
COL11A1-201
COL11A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COL11A1-001
ENSP00000359114
ENST00000370096
P12107 [Direct mapping]
Collagen alpha-1(XI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001502 [cartilage condensation]
GO:0001503 [ossification]
GO:0002063 [chondrocyte development]
GO:0003007 [heart morphogenesis]
GO:0005201 [extracellular matrix structural constituent]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005592 [collagen type XI trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006029 [proteoglycan metabolic process]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0030674 [protein binding, bridging]
GO:0031012 [extracellular matrix]
GO:0035987 [endodermal cell differentiation]
GO:0035989 [tendon development]
GO:0042472 [inner ear morphogenesis]
GO:0046872 [metal ion binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048705 [skeletal system morphogenesis]
GO:0050840 [extracellular matrix binding]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0051216 [cartilage development]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
Show all
 1806 aa
181.1 kDa 		Yes 0
COL11A1-002
ENSP00000408640
ENST00000427239
C9JMN2 [Direct mapping]
Collagen alpha-1(XI) chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 570 aa
62 kDa 		Yes 0
COL11A1-003
ENSP00000410177
ENST00000447608
H7C381 [Direct mapping]
Collagen alpha-1(XI) chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 200 aa
22.5 kDa 		No 0
COL11A1-008
ENSP00000426533
ENST00000512756
P12107 [Direct mapping]
Collagen alpha-1(XI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005592 [collagen type XI trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0030674 [protein binding, bridging]
GO:0035987 [endodermal cell differentiation]
GO:0046872 [metal ion binding]
GO:0050840 [extracellular matrix binding]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
Show all
 1690 aa
167.8 kDa 		Yes 0
COL11A1-201
ENSP00000302551
ENST00000353414
P12107 [Direct mapping]
Collagen alpha-1(XI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005592 [collagen type XI trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0030674 [protein binding, bridging]
GO:0035987 [endodermal cell differentiation]
GO:0046872 [metal ion binding]
GO:0050840 [extracellular matrix binding]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
Show all
 1767 aa
176.6 kDa 		Yes 0
COL11A1-202
ENSP00000351163
ENST00000358392
P12107 [Direct mapping]
Collagen alpha-1(XI) chain
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005592 [collagen type XI trimer]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007601 [visual perception]
GO:0007605 [sensory perception of sound]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0030674 [protein binding, bridging]
GO:0035987 [endodermal cell differentiation]
GO:0046872 [metal ion binding]
GO:0050840 [extracellular matrix binding]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
Show all
 1818 aa
182.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.