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A majority of cancer tissues showed weak to moderate cytoplasmic and nuclear positivity. Follicular adenocarcinoma of thyroid showed strong nuclear staining. Renal and skin cancers along with several lymphomas, testicular, endometrial and cervical cancers were negative.
GENE INFORMATION
Gene name
RNF125 (HGNC Symbol)
Synonyms
FLJ20456
Description
Ring finger protein 125, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]