Tissue expression of CYTH1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CYTH1
Gene description	Cytohesin 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CYTH1 (HGNC Symbol)
Synonyms	B2-1, cytohesin-1, D17S811E, PSCD1
Description	Cytohesin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78674048 - 78782297
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108669 (version 83.38)
Entrez gene	9267
UniProt	Q15438 (UniProt - Evidence at protein level)
neXtProt	NX_Q15438
Antibodypedia	CYTH1 antibodies

PROTEIN BROWSER

CYTH1-001	CYTH1-002	CYTH1-005	CYTH1-006	CYTH1-012	CYTH1-015	CYTH1-016	CYTH1-018	CYTH1-020	CYTH1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYTH1-001 ENSP00000389095 ENST00000446868	Q15438 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008289 [lipid binding] GO:0016192 [vesicle-mediated transport] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	398 aa 46.4 kDa	No	0
CYTH1-002 ENSP00000465665 ENST00000591455	Q15438 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008289 [lipid binding] GO:0016192 [vesicle-mediated transport] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	397 aa 46.4 kDa	No	0
CYTH1-005 ENSP00000468433 ENST00000586043	K7ERV8 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	194 aa 22.4 kDa	No	0
CYTH1-006 ENSP00000466949 ENST00000590300	K7ENH6 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	86 aa 10 kDa	No	0
CYTH1-012 ENSP00000465252 ENST00000589296	K7EJN5 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.6 kDa	No	0
CYTH1-015 ENSP00000466512 ENST00000589297	Q15438 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008289 [lipid binding] GO:0016192 [vesicle-mediated transport] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	339 aa 39.5 kDa	No	0
CYTH1-016 ENSP00000465940 ENST00000585509	Q15438 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0008289 [lipid binding] GO:0016192 [vesicle-mediated transport] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	339 aa 39.5 kDa	No	0
CYTH1-018 ENSP00000467052 ENST00000589768	K7ENQ8 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	272 aa 31.7 kDa	No	0
CYTH1-020 ENSP00000465530 ENST00000587308	K7EKA2 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	104 aa 12.2 kDa	No	0
CYTH1-201 ENSP00000354398 ENST00000361101	Q15438 [Direct mapping] Cytohesin-1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0008289 [lipid binding] GO:0016192 [vesicle-mediated transport] GO:0030155 [regulation of cell adhesion] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0090162 [establishment of epithelial cell polarity] Show all	398 aa 46.4 kDa	No	0