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Basal cell carcinomas along with a few cases of cholangiocarcinomas, malignant lymphomas, breast, prostate, ovarian and colorectal cancers showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
Cases of non-Hodgkins lymphomas and lung cancers displayed moderate to strong cytoplasmic positivity while a few seminomas showed moderate cytoplasmic and nuclear immunoreactivity. Remaining cancer tissues were in general weakly stained or negative.
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]