Tissue expression of FGF6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FGF6
Gene description	Fibroblast growth factor 6
Protein class	Cancer-related genes Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)
FANTOM5:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION
Gene name	FGF6
Synonyms
Description	Fibroblast growth factor 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.32
Chromosome location (bp)	4428155 - 4445614
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111241 (version 83.38)
Entrez gene	2251
UniProt	P10767 (UniProt - Evidence at protein level)
neXtProt	NX_P10767
Antibodypedia	FGF6 antibodies

PROTEIN BROWSER

FGF6-001	FGF6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FGF6-001 ENSP00000228837 ENST00000228837	P10767 [Direct mapping] Fibroblast growth factor 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001502 [cartilage condensation] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042383 [sarcolemma] GO:0045087 [innate immune response] GO:0045445 [myoblast differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] Show all	208 aa 22.9 kDa	No	0
FGF6-002 ENSP00000445479 ENST00000543077	H0YGZ9 [Direct mapping] Fibroblast growth factor 6 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005104 [fibroblast growth factor receptor binding] GO:0005576 [extracellular region] GO:0008083 [growth factor activity] GO:0008543 [fibroblast growth factor receptor signaling pathway] Show all	31 aa 3.4 kDa	No	0