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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

FN1

Gene descriptioni

Gene description according to HGNC.

Fibronectin 1

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Secreted

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue categoryi

The RNA tissue category is based on mRNA expression levels in the analyzed tissues (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA tissue category is calculated separately both for internally generated Human Protein Atlas (HPA) RNA-seq data, as well as RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project.

Read more

HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expressioni

A summary of the overall protein expression pattern across the analyzed tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Positivity in extracellular matrix and stromal cells.

DATA RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 2 antibodies.
HPA027066 , CAB000126
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARYi

Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.

RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.

Read more
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEWi

Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.

For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.

HPA dataseti

HPA dataset
RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.

RNA tissue category HPA
HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataseti

GTEx dataset
RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.

RNA tissue category GTEx
GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti

FANTOM5 dataset
Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.

RNA tissue category FANTOM5
FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

FN1 (HGNC Symbol)

Synonyms

CIG, FINC, GFND2, LETS, MSF

Description

Fibronectin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q35

Chromosome location (bp)

215360440 - 215436172

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115414 (version 83.38)

Entrez gene

2335

UniProt

P02751 (UniProt - Evidence at protein level)

neXtProt

NX_P02751

Antibodypedia

FN1 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
FN1-001
FN1-002
FN1-003
FN1-004
FN1-005
FN1-008
FN1-009
FN1-011
FN1-012
FN1-013
FN1-014
FN1-026
FN1-201
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FN1-001
ENSP00000346839
ENST00000354785
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001775 [cell activation]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0002931 [response to ischemia]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005604 [basement membrane]
GO:0005605 [basal lamina]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008347 [glial cell migration]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010193 [response to ozone]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0035987 [endodermal cell differentiation]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0042060 [wound healing]
GO:0043066 [negative regulation of apoptotic process]
GO:0045340 [mercury ion binding]
GO:0045773 [positive regulation of axon extension]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0050921 [positive regulation of chemotaxis]
GO:0051384 [response to glucocorticoid]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071288 [cellular response to mercury ion]
GO:0071333 [cellular response to glucose stimulus]
GO:0071347 [cellular response to interleukin-1]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071773 [cellular response to BMP stimulus]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2477 aa
272.3 kDa
Yes 0
FN1-002
ENSP00000323534
ENST00000323926
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2446 aa
268.9 kDa
Yes 0
FN1-003
ENSP00000338200
ENST00000336916
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2355 aa
259.2 kDa
Yes 0
FN1-004
ENSP00000350534
ENST00000357867
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2176 aa
239.6 kDa
Yes 0
FN1-005
ENSP00000394423
ENST00000421182
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2240 aa
246.7 kDa
Yes 0
FN1-008
ENSP00000410422
ENST00000446046
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2330 aa
256.5 kDa
Yes 0
FN1-009
ENSP00000415018
ENST00000443816
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2265 aa
249.4 kDa
Yes 0
FN1-011
ENSP00000416139
ENST00000456923
H0Y7Z1 [Direct mapping]
Fibronectin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
1103 aa
120.8 kDa
No 0
FN1-012
ENSP00000399538
ENST00000432072
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2267 aa
249.3 kDa
Yes 0
FN1-013
ENSP00000348285
ENST00000356005
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2296 aa
252.8 kDa
Yes 0
FN1-014
ENSP00000398907
ENST00000426059
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
657 aa
73.7 kDa
Yes 0
FN1-026
ENSP00000392565
ENST00000438981
H0Y4K8 [Direct mapping]
Fibronectin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
241 aa
26.6 kDa
No 0
FN1-201
ENSP00000352696
ENST00000359671
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0018149 [peptide cross-linking]
GO:0022617 [extracellular matrix disassembly]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0072562 [blood microparticle]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
GO:2001202 [negative regulation of transforming growth factor-beta secretion]
Show all
2386 aa
262.6 kDa
Yes 0

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