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NR5A2

CANCER ATLASi

Gene description

 Nuclear receptor subfamily 5, group A, member 2

Protein class

 Nuclear receptors, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARYi
HPA005455
HPA017067

GENE INFORMATIONi

Gene name

 NR5A2 (HGNC Symbol)

Synonyms

 B1F2, FTF, FTZ-F1, FTZ-F1beta, hB1F, hB1F-2, LRH-1

Description

 Nuclear receptor subfamily 5, group A, member 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 200027602 - 200177424

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116833 (version 83.38)

Entrez gene

 2494

UniProt

 O00482 (UniProt - Evidence at protein level)

neXtProt

 NX_O00482

Antibodypedia

 NR5A2 antibodies

PROTEIN BROWSERi
NR5A2-001
NR5A2-003
NR5A2-004
NR5A2-005
NR5A2-201

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR5A2-001
ENSP00000356331
ENST00000367362
O00482 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009790 [embryo development]
GO:0009888 [tissue development]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030855 [epithelial cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0042127 [regulation of cell proliferation]
GO:0042592 [homeostatic process]
GO:0042632 [cholesterol homeostasis]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0061113 [pancreas morphogenesis]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 541 aa
61.3 kDa 		No 0
NR5A2-003
ENSP00000236914
ENST00000236914
O00482 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
F1D8R9 [Target identity:100%; Query identity:100%]
Liver nuclear receptor homolog-1 variant 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009790 [embryo development]
GO:0009888 [tissue development]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031018 [endocrine pancreas development]
GO:0042592 [homeostatic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 495 aa
56.5 kDa 		No 0
NR5A2-004
ENSP00000414888
ENST00000447034
H0Y7S7 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
Show all
Predicted intracellular proteins
Show all
 71 aa
7.5 kDa 		No 0
NR5A2-005
ENSP00000356326
ENST00000367357
H0Y328 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 377 aa
42 kDa 		No 0
NR5A2-201
ENSP00000439116
ENST00000544748
O00482 [Direct mapping]
Nuclear receptor subfamily 5 group A member 2
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009790 [embryo development]
GO:0009888 [tissue development]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0031018 [endocrine pancreas development]
GO:0042592 [homeostatic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 469 aa
53.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.