Tissue expression of MYRF - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MYRF
Gene description	Myelin regulatory factor
Protein class	Enzymes Plasma proteins Predicted membrane proteins Transcription factors
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, stomach)
GTEx:	Tissue enhanced (stomach)
FANTOM5:	Tissue enhanced (brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, stomach)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (stomach)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain)

GENE INFORMATION
Gene name	MYRF (HGNC Symbol)
Synonyms	C11orf9, MRF, Ndt80, pqn-47
Description	Myelin regulatory factor (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61752642 - 61788518
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124920 (version 83.38)
Entrez gene	745
UniProt	Q9Y2G1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2G1
Antibodypedia	MYRF antibodies

PROTEIN BROWSER

MYRF-001	MYRF-002	MYRF-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYRF-001 ENSP00000278836 ENST00000278836	Q9Y2G1 [Direct mapping] Myelin regulatory factor Myelin regulatory factor, N-terminal Myelin regulatory factor, C-terminal Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0014003 [oligodendrocyte development] GO:0016021 [integral component of membrane] GO:0022010 [central nervous system myelination] GO:0031643 [positive regulation of myelination] GO:0032286 [central nervous system myelin maintenance] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048709 [oligodendrocyte differentiation] Show all	1151 aa 124.4 kDa	No	1
MYRF-002 ENSP00000265460 ENST00000265460	Q9Y2G1 [Direct mapping] Myelin regulatory factor Myelin regulatory factor, N-terminal Myelin regulatory factor, C-terminal Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0014003 [oligodendrocyte development] GO:0016021 [integral component of membrane] GO:0022010 [central nervous system myelination] GO:0031643 [positive regulation of myelination] GO:0032286 [central nervous system myelin maintenance] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048709 [oligodendrocyte differentiation] Show all	1111 aa 120.2 kDa	No	1
MYRF-003 ENSP00000374253 ENST00000389602	B4DHB2 [Direct mapping] Myelin regulatory factor; cDNA FLJ59324 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	537 aa 57.5 kDa	No	1