Cell atlas - SOX21 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SOX21

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	SOX21
Gene description	SRY (sex determining region Y)-box 21
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (AF22, NTERA-2, PC-3)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064084
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, NTERA-2, PC-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064084	AF22	Nucleus
	HPA064084	PC-3	No staining

GENE INFORMATION
Gene name	SOX21 (HGNC Symbol)
Synonyms	SOX25
Description	SRY (sex determining region Y)-box 21 (HGNC Symbol)
Entrez gene summary	SRY-related HMG-box (SOX) genes encode a family of DNA-binding proteins containing a 79-amino acid HMG (high mobility group) domain that shares at least 50% sequence identity with the DNA-binding HMG box of the SRY protein (MIM 480000). SOX proteins are divided into 6 subgroups based on sequence similarity within and outside of the HMG domain. For additional background information on SOX genes, see SOX1 (MIM 602148).[supplied by OMIM, Apr 2004]
Chromosome	13
Cytoband	q32.1
Chromosome location (bp)	94709622 - 94712399
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000125285 (version 83.38)
Entrez gene	11166
UniProt	Q9Y651 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y651
Antibodypedia	SOX21 antibodies

PROTEIN BROWSER

SOX21-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOX21-001 ENSP00000366144 ENST00000376945	Q9Y651 [Direct mapping] Transcription factor SOX-21 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001942 [hair follicle development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0042633 [hair cycle] GO:0043588 [skin development] GO:0048863 [stem cell differentiation] Show all	276 aa 28.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.