We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
BCL2L2
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

BCL2-like 2

Protein class

Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

CAB040539

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells displayed moderate cytoplasmic positivity. Thyroid cancers along with a few cases of malignant melanomas, ovarian, lung and pancreatic cancers exhibited strong staining.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

BCL2L2 (HGNC Symbol)

Synonyms

BCL-W, KIAA0271, PPP1R51

Description

BCL2-like 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

23298790 - 23311759

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129473 (version 83.38)

Entrez gene

599

UniProt

Q92843 (UniProt - Evidence at protein level)

neXtProt

NX_Q92843

Antibodypedia

BCL2L2 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

BCL2L2-001
BCL2L2-002
BCL2L2-003
BCL2L2-004
BCL2L2-005
BCL2L2-006

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2L2-001
ENSP00000250405
ENST00000250405
Q92843 [Direct mapping]
Bcl-2-like protein 2
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007283 [spermatogenesis]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0031966 [mitochondrial membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0051400 [BH domain binding]
GO:0060011 [Sertoli cell proliferation]
GO:0070062 [extracellular exosome]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
193 aa
20.7 kDa
No 2
BCL2L2-002
ENSP00000451148
ENST00000553824
G3V3B7 [Direct mapping]
Bcl-2-like protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
51 aa
5.2 kDa
No 0
BCL2L2-003
ENSP00000451701
ENST00000557236
G3V4B7 [Direct mapping]
Bcl-2-like protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
149 aa
16.2 kDa
No 0
BCL2L2-004
ENSP00000452265
ENST00000557579
G3V5A9 [Direct mapping]
Bcl-2-like protein 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
144 aa
15.7 kDa
No 0
BCL2L2-005
ENSP00000451234
ENST00000554635
G3V3G8 [Direct mapping]
Bcl-2-like protein 2
Show all
Predicted intracellular proteins
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
72 aa
7.7 kDa
No 0
BCL2L2-006
ENSP00000451197
ENST00000556599
H0YJC7 [Direct mapping]
Bcl-2-like protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005741 [mitochondrial outer membrane]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016021 [integral component of membrane]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
167 aa
18.1 kDa
No 2

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.