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Cases of urothelial cancers showed moderate to strong membranous and cytoplasmic staining while several colorectal, ovarian, gastric, pancreatic and liver cancers displayed moderate membranous staining. Remaining cancer tissues were negative or weakly stained.
A majority of colorectal cancers showed moderate to strong staining while several cases of melanomas, thyroid, ovarian, skin, pancreatic and hepatocellular cancers were moderately stained. Remaining cancer tissues were weakly stained.
GENE INFORMATION
Gene name
MYO7A (HGNC Symbol)
Synonyms
DFNA11, DFNB2, NSRD2, USH1B
Description
Myosin VIIA (HGNC Symbol)
Entrez gene summary
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014)