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CELA1

GENERAL INFORMATION

Gene name

 CELA1

Gene description

 Chymotrypsin-like elastase family, member 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland, pancreas)
GTEx:Tissue enhanced (adrenal gland)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, pancreas)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland)

GENE INFORMATION

Gene name

 CELA1 (HGNC Symbol)

Synonyms

 ELA1

Description

 Chymotrypsin-like elastase family, member 1 (HGNC Symbol)

Entrez gene summary

 Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 51328443 - 51346679

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139610 (version 83.38)

Entrez gene

 1990

UniProt

 Q9UNI1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNI1

Antibodypedia

 CELA1 antibodies

PROTEIN BROWSER
CELA1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CELA1-001
ENSP00000293636
ENST00000293636
Q9UNI1 [Direct mapping]
Chymotrypsin-like elastase family member 1
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004252 [serine-type endopeptidase activity]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0006954 [inflammatory response]
GO:0009791 [post-embryonic development]
GO:0016055 [Wnt signaling pathway]
GO:0031017 [exocrine pancreas development]
GO:0035264 [multicellular organism growth]
GO:0042127 [regulation of cell proliferation]
GO:0045595 [regulation of cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048771 [tissue remodeling]
GO:0055123 [digestive system development]
GO:0060309 [elastin catabolic process]
GO:0061113 [pancreas morphogenesis]
Show all
 258 aa
27.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.