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Term
Gene name

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Reliability

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Validation

Method

Validation

Method

Validation

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Searches

Tissue

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Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

Score

Antibodies

Column

 
 
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ADAMTS10
  • TISSUE

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  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 10

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

HPA040223

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer cells showed weak to moderate cytoplasmic positivity. A few squamous cell carcinomas of cervix and ovarian cancers were strongly stained. Most cases of lymphoma, gastric, pancreatic and liver cancer were negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ADAMTS10 (HGNC Symbol)

Synonyms

ADAM-TS10

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 10 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

8580242 - 8610735

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142303 (version 83.38)

Entrez gene

81794

UniProt

Q9H324 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H324

Antibodypedia

ADAMTS10 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

ADAMTS10-001
ADAMTS10-003
ADAMTS10-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS10-001
ENSP00000471851
ENST00000597188
A0A0A0MQW6 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
1103 aa
120.9 kDa
Yes 0
ADAMTS10-003
ENSP00000470501
ENST00000595838
Q9H324 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 10
Show all
Enzymes
   Peptidases
   Metallopeptidases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0001527 [microfibril]
GO:0003674 [molecular_function]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0008150 [biological_process]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
590 aa
62.5 kDa
No 0
ADAMTS10-201
ENSP00000270328
ENST00000270328
A0A0A0MQW6 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 10
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
1103 aa
120.9 kDa
Yes 0

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