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Malignant melanomas distinct cytoplasmic immunoreactivity. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
SNCA (HGNC Symbol)
Synonyms
alpha-synuclein, NACP, PARK1, PARK4, PD1
Description
Synuclein, alpha (non A4 component of amyloid precursor) (HGNC Symbol)
Entrez gene summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0001933 [negative regulation of protein phosphorylation] GO:0001956 [positive regulation of neurotransmitter secretion] GO:0001963 [synaptic transmission, dopaminergic] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005640 [nuclear outer membrane] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006631 [fatty acid metabolic process] GO:0006638 [neutral lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007006 [mitochondrial membrane organization] GO:0007268 [synaptic transmission] GO:0007568 [aging] GO:0008017 [microtubule binding] GO:0008021 [synaptic vesicle] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0008344 [adult locomotory behavior] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014048 [regulation of glutamate secretion] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030659 [cytoplasmic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0040012 [regulation of locomotion] GO:0042220 [response to cocaine] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042417 [dopamine metabolic process] GO:0042493 [response to drug] GO:0042775 [mitochondrial ATP synthesis coupled electron transport] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043030 [regulation of macrophage activation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043195 [terminal bouton] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0043231 [intracellular membrane-bounded organelle] GO:0043274 [phospholipase binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043679 [axon terminus] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045202 [synapse] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0045963 [negative regulation of dopamine metabolic process] GO:0046928 [regulation of neurotransmitter secretion] GO:0047485 [protein N-terminus binding] GO:0048148 [behavioral response to cocaine] GO:0048156 [tau protein binding] GO:0048168 [regulation of neuronal synaptic plasticity] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048471 [perinuclear region of cytoplasm] GO:0048487 [beta-tubulin binding] GO:0048488 [synaptic vesicle endocytosis] GO:0048489 [synaptic vesicle transport] GO:0050544 [arachidonic acid binding] GO:0050806 [positive regulation of synaptic transmission] GO:0050808 [synapse organization] GO:0050812 [regulation of acyl-CoA biosynthetic process] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060079 [excitatory postsynaptic potential] GO:0060291 [long-term synaptic potentiation] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0061024 [membrane organization] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1901214 [regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:2000377 [regulation of reactive oxygen species metabolic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043205 [fibril] GO:0043206 [extracellular fibril organization] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045502 [dynein binding] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process]