Tissue expression of CPLX2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CPLX2
Gene description	Complexin 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, epididymis)
GTEx:	Tissue enhanced (cerebellum, hippocampus, cerebral cortex)
FANTOM5:	Tissue enhanced (hippocampus, brain, cerebellum)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, hippocampus, cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus, brain, cerebellum)

GENE INFORMATION
Gene name	CPLX2 (HGNC Symbol)
Synonyms	CPX-2, DKFZp547D155
Description	Complexin 2 (HGNC Symbol)
Entrez gene summary	Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	175796310 - 175884020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145920 (version 83.38)
Entrez gene	10814
UniProt	Q6PUV4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6PUV4
Antibodypedia	CPLX2 antibodies

PROTEIN BROWSER

CPLX2-001	CPLX2-003	CPLX2-004	CPLX2-005	CPLX2-006	CPLX2-007	CPLX2-008	CPLX2-009	CPLX2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPLX2-001 ENSP00000352544 ENST00000359546	Q6PUV4 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0005829 [cytosol] GO:0006836 [neurotransmitter transport] GO:0006904 [vesicle docking involved in exocytosis] GO:0007399 [nervous system development] GO:0016079 [synaptic vesicle exocytosis] GO:0017075 [syntaxin-1 binding] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0030154 [cell differentiation] GO:0030425 [dendrite] GO:0031201 [SNARE complex] GO:0031915 [positive regulation of synaptic plasticity] GO:0042629 [mast cell granule] GO:0043025 [neuronal cell body] GO:0043195 [terminal bouton] GO:0043303 [mast cell degranulation] GO:0045202 [synapse] GO:0048306 [calcium-dependent protein binding] GO:0070033 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex] GO:0070554 [synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex] Show all	134 aa 15.4 kDa	No	0
CPLX2-003 ENSP00000377346 ENST00000393745	Q6PUV4 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006836 [neurotransmitter transport] GO:0006904 [vesicle docking involved in exocytosis] GO:0007399 [nervous system development] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0030154 [cell differentiation] GO:0031915 [positive regulation of synaptic plasticity] GO:0042629 [mast cell granule] GO:0043303 [mast cell degranulation] GO:0070554 [synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex] Show all	134 aa 15.4 kDa	No	0
CPLX2-004 ENSP00000425973 ENST00000512824	D6RI05 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006836 [neurotransmitter transport] GO:0019905 [syntaxin binding] Show all	70 aa 8.2 kDa	No	0
CPLX2-005 ENSP00000425284 ENST00000515025	D6RDN3 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006836 [neurotransmitter transport] GO:0019905 [syntaxin binding] Show all	37 aa 4.1 kDa	No	0
CPLX2-006 ENSP00000421825 ENST00000515094	Q6PUV4 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0006836 [neurotransmitter transport] GO:0006904 [vesicle docking involved in exocytosis] GO:0007399 [nervous system development] GO:0017157 [regulation of exocytosis] GO:0019905 [syntaxin binding] GO:0030154 [cell differentiation] GO:0031915 [positive regulation of synaptic plasticity] GO:0042629 [mast cell granule] GO:0043303 [mast cell degranulation] GO:0070554 [synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex] Show all	134 aa 15.4 kDa	No	0
CPLX2-007 ENSP00000423612 ENST00000514150	D6R960 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006836 [neurotransmitter transport] GO:0019905 [syntaxin binding] Show all	119 aa 13.6 kDa	No	0
CPLX2-008 ENSP00000424305 ENST00000502265	D6RBA5 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006836 [neurotransmitter transport] GO:0019905 [syntaxin binding] Show all	77 aa 9.1 kDa	No	0
CPLX2-009 ENSP00000423564 ENST00000515502		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.8 kDa	No	0
CPLX2-011 ENSP00000421106 ENST00000509837	D6RGY3 [Direct mapping] Complexin-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006836 [neurotransmitter transport] GO:0019905 [syntaxin binding] Show all	111 aa 12.7 kDa	No	0