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Prostate, urothelial, thyroid cancers along with few breast and pancreatic cancers showed moderate cytoplasmic and nuclear positivity. Other cancer tissues tissues were weakly stained or negative.
GENE INFORMATION
Gene name
JPH2 (HGNC Symbol)
Synonyms
JP-2
Description
Junctophilin 2 (HGNC Symbol)
Entrez gene summary
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008]