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PPP1R1C

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GENERAL INFORMATION

Gene name

 PPP1R1C

Gene description

 Protein phosphatase 1, regulatory (inhibitor) subunit 1C

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli & the Golgi apparatus.

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved)

Additional location

 In addition localized to the Nucleoli (approved), Golgi apparatus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA055043
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli & the Golgi apparatus.

Main location

 Nucleus (approved)

Additional location

 Nucleoli (approved), Golgi apparatus (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA055043 MCF7 Nucleus
Nucleoli
Golgi apparatus
HPA055043 RT4 Nucleoplasm
HPA055043 U-2 OS Nucleus
Golgi apparatus

GENE INFORMATION

Gene name

 PPP1R1C (HGNC Symbol)

Synonyms

 Inhibitor-1-like

Description

 Protein phosphatase 1, regulatory (inhibitor) subunit 1C (HGNC Symbol)

Entrez gene summary

 Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

Chromosome

 2

Cytoband

Chromosome location (bp)

 181954241 - 182131398

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150722 (version 83.38)

Entrez gene

 151242

UniProt

 Q8WVI7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WVI7

Antibodypedia

 PPP1R1C antibodies

PROTEIN BROWSER
PPP1R1C-003
PPP1R1C-004
PPP1R1C-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R1C-003
ENSP00000386359
ENST00000409137
Q8WVI7 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1C
Show all
Predicted intracellular proteins
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0030307 [positive regulation of cell growth]
GO:0035556 [intracellular signal transduction]
GO:0051301 [cell division]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
Show all
 109 aa
12.3 kDa 		No 0
PPP1R1C-004
ENSP00000280295
ENST00000280295
Q8WVI7 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1C
Show all
Predicted intracellular proteins
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0030307 [positive regulation of cell growth]
GO:0035556 [intracellular signal transduction]
GO:0051301 [cell division]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
Show all
 116 aa
13.1 kDa 		No 0
PPP1R1C-005
ENSP00000386778
ENST00000409702
Q8WVI7 [Direct mapping]
Protein phosphatase 1 regulatory subunit 1C
Show all
Predicted intracellular proteins
Show all
GO:0004864 [protein phosphatase inhibitor activity]
GO:0004865 [protein serine/threonine phosphatase inhibitor activity]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0030307 [positive regulation of cell growth]
GO:0035556 [intracellular signal transduction]
GO:0051301 [cell division]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
Show all
 109 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.