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Gene name

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Reliability

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Method

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Searches

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KCNJ1
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  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

KCNJ1

Gene description

Potassium channel, inwardly rectifying subfamily J, member 1

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in renal tubules.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
HPA026962
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

KCNJ1 (HGNC Symbol)

Synonyms

Kir1.1, ROMK1

Description

Potassium channel, inwardly rectifying subfamily J, member 1 (HGNC Symbol)

Entrez gene summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q24.3

Chromosome location (bp)

128836315 - 128867373

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151704 (version 83.38)

Entrez gene

3758

UniProt

P48048 (UniProt - Evidence at protein level)

neXtProt

NX_P48048

Antibodypedia

KCNJ1 antibodies

PROTEIN BROWSER

KCNJ1-001
KCNJ1-002
KCNJ1-003
KCNJ1-004
KCNJ1-005
KCNJ1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNJ1-001
ENSP00000316233
ENST00000324036
P48048 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 1
A0A024R3K6 [Target identity:100%; Query identity:100%]
Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007588 [excretion]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
372 aa
42.7 kDa
No 2
KCNJ1-002
ENSP00000316136
ENST00000324003
A0A0C4DFP9 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
139 aa
16.3 kDa
No 1
KCNJ1-003
ENSP00000406320
ENST00000440599
P48048 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 1
A0A024R3K6 [Target identity:100%; Query identity:100%]
Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007588 [excretion]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
372 aa
42.7 kDa
No 2
KCNJ1-004
ENSP00000376432
ENST00000392664
P48048 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001822 [kidney development]
GO:0001894 [tissue homeostasis]
GO:0005242 [inward rectifier potassium channel activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007588 [excretion]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009791 [post-embryonic development]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035864 [response to potassium ion]
GO:0042277 [peptide binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0070294 [renal sodium ion absorption]
GO:0071286 [cellular response to magnesium ion]
GO:0072358 [cardiovascular system development]
GO:1900128 [regulation of G-protein activated inward rectifier potassium channel activity]
Show all
391 aa
44.8 kDa
No 2
KCNJ1-005
ENSP00000376433
ENST00000392665
P48048 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 1
A0A024R3K6 [Target identity:100%; Query identity:100%]
Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007588 [excretion]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
372 aa
42.7 kDa
No 2
KCNJ1-201
ENSP00000376434
ENST00000392666
P48048 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 1
A0A024R3K6 [Target identity:100%; Query identity:100%]
Potassium inwardly-rectifying channel, subfamily J, member 1, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005524 [ATP binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007588 [excretion]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
372 aa
42.7 kDa
No 2

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.