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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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KCNJ16
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

Potassium channel, inwardly rectifying subfamily J, member 16

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

HPA059563

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues displayed weak to moderate cytoplasmic staining with additional nuclear positivity in few cases. Most of the cases of papillary carcinoma of thyroid along with few cases of lymphomas, endometrial, colorectal, breast and liver cancers were strongly positive. Majority of the cases of lymphomas, ovarian, cervical and skin cancers were negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

KCNJ16 (HGNC Symbol)

Synonyms

BIR9, Kir5.1

Description

Potassium channel, inwardly rectifying subfamily J, member 16 (HGNC Symbol)

Entrez gene summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Chromosome

17

Cytoband

q24.3

Chromosome location (bp)

70053429 - 70135608

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000153822 (version 83.38)

Entrez gene

3773

UniProt

Q9NPI9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NPI9

Antibodypedia

KCNJ16 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

KCNJ16-001
KCNJ16-002
KCNJ16-006
KCNJ16-008
KCNJ16-009
KCNJ16-010
KCNJ16-201
KCNJ16-202
KCNJ16-203
KCNJ16-204

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNJ16-001
ENSP00000465295
ENST00000585558
K7EJR9 [Direct mapping]
Inward rectifier potassium channel 16; Potassium inwardly-rectifying channel, subfamily J, member 16, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0071804 [cellular potassium ion transport]
Show all
453 aa
51.9 kDa
No 2
KCNJ16-002
ENSP00000465967
ENST00000589377
Q9NPI9 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
418 aa
47.9 kDa
No 2
KCNJ16-006
ENSP00000467568
ENST00000586462
K7EPW9 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
457 aa
52.4 kDa
No 2
KCNJ16-008
ENSP00000465646
ENST00000591891
K7EKJ4 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Predicted intracellular proteins
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0010107 [potassium ion import]
GO:0034765 [regulation of ion transmembrane transport]
Show all
35 aa
4.2 kDa
No 0
KCNJ16-009
ENSP00000466132
ENST00000587698
K7ELL5 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Predicted intracellular proteins
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
64 aa
7.5 kDa
No 0
KCNJ16-010
ENSP00000465163
ENST00000587892
K7EKJ4 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Predicted intracellular proteins
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0010107 [potassium ion import]
GO:0034765 [regulation of ion transmembrane transport]
Show all
35 aa
4.2 kDa
No 0
KCNJ16-201
ENSP00000283936
ENST00000283936
Q9NPI9 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
418 aa
47.9 kDa
No 2
KCNJ16-202
ENSP00000376438
ENST00000392670
Q9NPI9 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
418 aa
47.9 kDa
No 2
KCNJ16-203
ENSP00000376439
ENST00000392671
Q9NPI9 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
418 aa
47.9 kDa
No 2
KCNJ16-204
ENSP00000479817
ENST00000615244
Q9NPI9 [Direct mapping]
Inward rectifier potassium channel 16
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010107 [potassium ion import]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
Show all
418 aa
47.9 kDa
No 2

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