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Most of the cancer tissues showed moderate cytoplasmic immunoreactivity with an additional nuclear positivity in a few cases. Several cases of melanomas, thyroid cancers, testis and prostate cancers expressed strong positivity.
GENE INFORMATION
Gene name
CBR3 (HGNC Symbol)
Synonyms
SDR21C2
Description
Carbonyl reductase 3 (HGNC Symbol)
Entrez gene summary
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008]
O75828 [Direct mapping] Carbonyl reductase [NADPH] 3 V9HW40 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 25
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Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)