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Weak to moderate cytoplasmic positivity was observed in most malignant gliomas, pancreatic and gastric cancers along with several malignant lymphomas, ovarian, renal and liver cancers. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
NEXN (HGNC Symbol)
Synonyms
NELIN, nexilin
Description
Nexilin (F actin binding protein) (HGNC Symbol)
Entrez gene summary
This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]