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Many renal cell carcinomas along with cases of female genital cancers showed moderate cytoplasmic and membranous staining. Cancer cells in general were negative.
Renal cancers showed moderate membranous staining. Cancer cells in general were negative.
GENE INFORMATION
Gene name
CDH16
Synonyms
Description
Cadherin 16, KSP-cadherin (HGNC Symbol)
Entrez gene summary
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]