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E2F6

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GENERAL INFORMATION

Gene name

 E2F6

Gene description

 E2F transcription factor 6

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & nucleoli.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA065719
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & nucleoli.

Main location

 Nucleus (supported), Nucleoli (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA065719 CACO-2 Nucleoplasm
HPA065719 SH-SY5Y Nucleus
Nucleoli Intensity
HPA065719 U-2 OS Nucleus
Nucleoli

GENE INFORMATION

Gene name

 E2F6 (HGNC Symbol)

Synonyms

 E2F-6

Description

 E2F transcription factor 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 11444375 - 11466177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169016 (version 83.38)

Entrez gene

 1876

UniProt

 O75461 (UniProt - Evidence at protein level)

neXtProt

 NX_O75461

Antibodypedia

 E2F6 antibodies

PROTEIN BROWSER
E2F6-001
E2F6-201
E2F6-202
E2F6-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
E2F6-001
ENSP00000370936
ENST00000381525
O75461 [Direct mapping]
Transcription factor E2F6
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0071339 [MLL1 complex]
Show all
 281 aa
31.8 kDa 		No 0
E2F6-201
ENSP00000302159
ENST00000307236
O75461 [Direct mapping]
Transcription factor E2F6
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0071339 [MLL1 complex]
Show all
 249 aa
28.1 kDa 		No 0
E2F6-202
ENSP00000446315
ENST00000542100
O75461 [Direct mapping]
Transcription factor E2F6
Q53YM3 [Target identity:100%; Query identity:100%]
E2F transcription factor 6, isoform CRA_d; E2F6 splice variant c; E2F6 splice variant d; E2F6 splice variant e; cDNA FLJ38878 fis, clone MESAN2015365, highly similar to TRANSCRIPTION FACTOR E2F6
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0071339 [MLL1 complex]
Show all
 206 aa
23 kDa 		No 0
E2F6-203
ENSP00000438864
ENST00000546212
O75461 [Direct mapping]
Transcription factor E2F6
Q53YM3 [Target identity:100%; Query identity:100%]
E2F transcription factor 6, isoform CRA_d; E2F6 splice variant c; E2F6 splice variant d; E2F6 splice variant e; cDNA FLJ38878 fis, clone MESAN2015365, highly similar to TRANSCRIPTION FACTOR E2F6
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0071339 [MLL1 complex]
Show all
 206 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.