Tissue expression of E2F6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	E2F6
Gene description	E2F transcription factor 6
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	E2F6 (HGNC Symbol)
Synonyms	E2F-6
Description	E2F transcription factor 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	11444375 - 11466177
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169016 (version 83.38)
Entrez gene	1876
UniProt	O75461 (UniProt - Evidence at protein level)
neXtProt	NX_O75461
Antibodypedia	E2F6 antibodies

PROTEIN BROWSER

E2F6-001	E2F6-201	E2F6-202	E2F6-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
E2F6-001 ENSP00000370936 ENST00000381525	O75461 [Direct mapping] Transcription factor E2F6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0071339 [MLL1 complex] Show all	281 aa 31.8 kDa	No	0
E2F6-201 ENSP00000302159 ENST00000307236	O75461 [Direct mapping] Transcription factor E2F6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0071339 [MLL1 complex] Show all	249 aa 28.1 kDa	No	0
E2F6-202 ENSP00000446315 ENST00000542100	O75461 [Direct mapping] Transcription factor E2F6 Q53YM3 [Target identity:100%; Query identity:100%] E2F transcription factor 6, isoform CRA_d; E2F6 splice variant c; E2F6 splice variant d; E2F6 splice variant e; cDNA FLJ38878 fis, clone MESAN2015365, highly similar to TRANSCRIPTION FACTOR E2F6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0071339 [MLL1 complex] Show all	206 aa 23 kDa	No	0
E2F6-203 ENSP00000438864 ENST00000546212	O75461 [Direct mapping] Transcription factor E2F6 Q53YM3 [Target identity:100%; Query identity:100%] E2F transcription factor 6, isoform CRA_d; E2F6 splice variant c; E2F6 splice variant d; E2F6 splice variant e; cDNA FLJ38878 fis, clone MESAN2015365, highly similar to TRANSCRIPTION FACTOR E2F6 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0071339 [MLL1 complex] Show all	206 aa 23 kDa	No	0