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Gene name

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Reliability

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Method

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Method

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Searches

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Expression

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Cell line

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Detectable

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UMOD
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    TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

UMOD

Gene description

Uromodulin

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enriched (kidney)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in distal renal tubules.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA043420 , HPA054721 , CAB009446
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)

GENE INFORMATION

Gene name

UMOD

Synonyms

Description

Uromodulin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

16

Cytoband

p12.3

Chromosome location (bp)

20333052 - 20356301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169344 (version 83.38)

Entrez gene

7369

UniProt

P07911 (UniProt - Evidence at protein level)

neXtProt

NX_P07911

Antibodypedia

UMOD antibodies

PROTEIN BROWSER

«
UMOD-001
UMOD-002
UMOD-008
UMOD-009
UMOD-011
UMOD-012
UMOD-014
UMOD-015
UMOD-016
UMOD-017
UMOD-018
UMOD-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UMOD-001
ENSP00000379442
ENST00000396138
X6RBG4 [Direct mapping]
Uromodulin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
Show all
689 aa
75.7 kDa
No 2
UMOD-002
ENSP00000379438
ENST00000396134
P07911 [Direct mapping]
Uromodulin Uromodulin, secreted form
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005794 [Golgi apparatus]
GO:0006968 [cellular defense response]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007588 [excretion]
GO:0008285 [negative regulation of cell proliferation]
GO:0010033 [response to organic substance]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019864 [IgG binding]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0048878 [chemical homeostasis]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
GO:0072218 [metanephric ascending thin limb development]
GO:0072221 [metanephric distal convoluted tubule development]
GO:0072233 [metanephric thick ascending limb development]
GO:0072372 [primary cilium]
GO:1990266 [neutrophil migration]
GO:2000021 [regulation of ion homeostasis]
Show all
673 aa
73.6 kDa
Yes 1
UMOD-008
ENSP00000460548
ENST00000570689
P07911 [Direct mapping]
Uromodulin Uromodulin, secreted form
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006968 [cellular defense response]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0008285 [negative regulation of cell proliferation]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019864 [IgG binding]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:1990266 [neutrophil migration]
Show all
640 aa
69.8 kDa
Yes 1
UMOD-009
ENSP00000459738
ENST00000577168
I3L2K2 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
138 aa
14.9 kDa
Yes 0
UMOD-011
ENSP00000458939
ENST00000571174
I3L1M3 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
125 aa
13 kDa
Yes 0
UMOD-012
ENSP00000461641
ENST00000576688
I3L4Y6 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
Show all
103 aa
10.8 kDa
Yes 0
UMOD-014
ENSP00000459724
ENST00000570757
I3L2J2 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
88 aa
9.2 kDa
Yes 0
UMOD-015
ENSP00000458695
ENST00000570972
Q8NHW8 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
29 aa
3.1 kDa
No 0
UMOD-016
ENSP00000461120
ENST00000576546
I3L4B0 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
86 aa
9.1 kDa
Yes 0
UMOD-017
ENSP00000460845
ENST00000574195
I3L3Z4 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005201 [extracellular matrix structural constituent]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
Show all
161 aa
17.6 kDa
Yes 0
UMOD-018
ENSP00000460374
ENST00000573567
I3L3E0 [Direct mapping]
Uromodulin
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
161 aa
17.1 kDa
Yes 0
UMOD-201
ENSP00000306279
ENST00000302509
P07911 [Direct mapping]
Uromodulin Uromodulin, secreted form
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000922 [spindle pole]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006968 [cellular defense response]
GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0008285 [negative regulation of cell proliferation]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019864 [IgG binding]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
GO:0072372 [primary cilium]
GO:1990266 [neutrophil migration]
Show all
640 aa
69.8 kDa
Yes 1

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