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Cancer tissues generally showed moderate to strong cytoplasmic positivity with a granular pattern. Cases of gastric, renal and skin cancers were weakly stained.
GENE INFORMATION
Gene name
CCDC8 (HGNC Symbol)
Synonyms
3M3, DKFZp564K0322, PPP1R20
Description
Coiled-coil domain containing 8 (HGNC Symbol)
Entrez gene summary
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3). [provided by RefSeq, Dec 2011]