Tissue expression of ESCO2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ESCO2
Gene description	Establishment of sister chromatid cohesion N-acetyltransferase 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (duodenum)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Tissue enhanced (small intestine, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (duodenum)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine, testis)

GENE INFORMATION
Gene name	ESCO2 (HGNC Symbol)
Synonyms	EFO2, RBS
Description	Establishment of sister chromatid cohesion N-acetyltransferase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p21.1
Chromosome location (bp)	27771949 - 27812640
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000171320 (version 83.38)
Entrez gene	157570
UniProt	Q56NI9 (UniProt - Evidence at protein level)
neXtProt	NX_Q56NI9
Antibodypedia	ESCO2 antibodies

PROTEIN BROWSER

ESCO2-001	ESCO2-004	ESCO2-005	ESCO2-006	ESCO2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ESCO2-001 ENSP00000306999 ENST00000305188	Q56NI9 [Direct mapping] N-acetyltransferase ESCO2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000785 [chromatin] GO:0001741 [XY body] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0004468 [lysine N-acetyltransferase activity, acting on acetyl phosphate as donor] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006275 [regulation of DNA replication] GO:0006302 [double-strand break repair] GO:0007059 [chromosome segregation] GO:0010369 [chromocenter] GO:0031618 [nuclear pericentric heterochromatin] GO:0034421 [post-translational protein acetylation] GO:0035861 [site of double-strand break] GO:0046872 [metal ion binding] GO:0071168 [protein localization to chromatin] Show all	601 aa 68.3 kDa	No	0
ESCO2-004 ENSP00000428435 ENST00000523566	E5RIE3 [Direct mapping] N-acetyltransferase ESCO2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] Show all	187 aa 21.7 kDa	No	0
ESCO2-005 ENSP00000428027 ENST00000519637	E5RFP7 [Direct mapping] N-acetyltransferase ESCO2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] Show all	133 aa 15.3 kDa	No	0
ESCO2-006 ENSP00000428959 ENST00000518262	H0YB88 [Direct mapping] N-acetyltransferase ESCO2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 19.6 kDa	No	0
ESCO2-201 ENSP00000380563 ENST00000397418	Q56NI9 [Direct mapping] N-acetyltransferase ESCO2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000785 [chromatin] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006275 [regulation of DNA replication] GO:0034421 [post-translational protein acetylation] GO:0046872 [metal ion binding] Show all	239 aa 27.5 kDa	No	0