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Moderate to strong cytoplasmic immunoreactivity was observed in papillary adenocarcinomas of thyroid and skin cancers along with several cervical and head & neck cancers. Several gliomas, colorectal, breast, urothelial cancers along with few prostate, ovarian and pancreatic cancers were weak to moderately stained. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
FRMD3 (HGNC Symbol)
Synonyms
EPB41L4O, MGC20553
Description
FERM domain containing 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]