The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
A majority of normal tissues showed weak to moderate cytoplasmic and nuclear positivity. Strong immunoreactivity was observed in hepatocytes, exocrine pancreas, Leydig cells, myoepithelial and muscle cells. Renal glomeruli, lymphoid tissues, glial cells and most squamous epithelium were negative.
Strong cytoplasmic positivity was observed in liver, stomach, Leydig cells in testis and myoepithelial cells in breast. Moderate staining was displayed in respiratory epithelia, intestine, gall bladder, renal tubules, breast glands, heart and smooth muscle cells. Remaining normal tissues were weakly stained or negative.
Renal tubules and Leydig cells showed strong cytoplasmic staining. Hepatocytes, adrenal gland and gall bladder displayed strong cytoplasmic and nuclear positivity. Respiratory epithelia showed strong cytoplasmic and membranous staining. Remaining normal tissues were negative.