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Squamous and basal cell carcinomas along with cases of urothelial cancers exhibited moderate to strong cytoplasmic immunoreactivity. Remaining cancer cells were weakly stained or negative.
This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]