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POLD4

GENERAL INFORMATION

Gene name

 POLD4

Gene description

 Polymerase (DNA-directed), delta 4, accessory subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 POLD4 (HGNC Symbol)

Synonyms

 p12, POLDS

Description

 Polymerase (DNA-directed), delta 4, accessory subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 67350777 - 67356972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000175482 (version 83.38)

Entrez gene

 57804

UniProt

 Q9HCU8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCU8

Antibodypedia

 POLD4 antibodies

PROTEIN BROWSER
POLD4-001
POLD4-002
POLD4-004
POLD4-005
POLD4-010
POLD4-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLD4-001
ENSP00000479678
ENST00000532830
E9PL15 [Direct mapping]
DNA polymerase delta subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 32 aa
3.8 kDa 		No 0
POLD4-002
ENSP00000481251
ENST00000529704
E9PL15 [Direct mapping]
DNA polymerase delta subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 32 aa
3.8 kDa 		No 0
POLD4-004
ENSP00000311368
ENST00000312419
Q9HCU8 [Direct mapping]
DNA polymerase delta subunit 4
A0A024R5D7 [Target identity:100%; Query identity:100%]
Polymerase (DNA-directed), delta 4, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043625 [delta DNA polymerase complex]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 107 aa
12.4 kDa 		No 0
POLD4-005
ENSP00000436361
ENST00000530584
E9PL15 [Direct mapping]
DNA polymerase delta subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 32 aa
3.8 kDa 		No 0
POLD4-010
ENSP00000433408
ENST00000531239
E9PL15 [Direct mapping]
DNA polymerase delta subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
Show all
 32 aa
3.8 kDa 		No 0
POLD4-013
ENSP00000444780
ENST00000539074
Q9HCU8 [Direct mapping]
DNA polymerase delta subunit 4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0019985 [translesion synthesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0043625 [delta DNA polymerase complex]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 79 aa
8.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.