Tissue expression of SLC17A8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC17A8
Gene description	Solute carrier family 17 (vesicular glutamate transporter), member 8
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (small intestine)
GTEx:	Tissue enriched (small intestine)
FANTOM5:	Tissue enhanced (hippocampus, retina)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus, retina)

GENE INFORMATION
Gene name	SLC17A8 (HGNC Symbol)
Synonyms	DFNA25, VGLUT3
Description	Solute carrier family 17 (vesicular glutamate transporter), member 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Chromosome	12
Cytoband	q23.1
Chromosome location (bp)	100357079 - 100422059
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179520 (version 83.38)
Entrez gene	246213
UniProt	Q8NDX2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NDX2
Antibodypedia	SLC17A8 antibodies

PROTEIN BROWSER

SLC17A8-001	SLC17A8-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC17A8-001 ENSP00000316909 ENST00000323346	Q8NDX2 [Direct mapping] Vesicular glutamate transporter 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0003407 [neural retina development] GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005737 [cytoplasm] GO:0005771 [multivesicular body] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006836 [neurotransmitter transport] GO:0007420 [brain development] GO:0007605 [sensory perception of sound] GO:0015293 [symporter activity] GO:0015813 [L-glutamate transport] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043204 [perikaryon] GO:0043679 [axon terminus] GO:0045202 [synapse] GO:0055085 [transmembrane transport] GO:0060076 [excitatory synapse] GO:0089711 [L-glutamate transmembrane transport] GO:0090102 [cochlea development] GO:0097440 [apical dendrite] GO:0097441 [basilar dendrite] GO:0097451 [glial limiting end-foot] GO:1990030 [pericellular basket] Show all	589 aa 65 kDa	No	>9
SLC17A8-002 ENSP00000376715 ENST00000392989	Q8NDX2 [Direct mapping] Vesicular glutamate transporter 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0006836 [neurotransmitter transport] GO:0007605 [sensory perception of sound] GO:0015293 [symporter activity] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0043005 [neuron projection] GO:0055085 [transmembrane transport] GO:0089711 [L-glutamate transmembrane transport] Show all	539 aa 59.1 kDa	No	>9