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PHLDA2

GENERAL INFORMATION

Gene name

 PHLDA2

Gene description

 Pleckstrin homology-like domain, family A, member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Mixed
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 PHLDA2 (HGNC Symbol)

Synonyms

 BWR1C, HLDA2, IPL, TSSC3

Description

 Pleckstrin homology-like domain, family A, member 2 (HGNC Symbol)

Entrez gene summary

 This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 2928273 - 2929455

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000181649 (version 83.38)

Entrez gene

 7262

UniProt

 Q53GA4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q53GA4

Antibodypedia

 PHLDA2 antibodies

PROTEIN BROWSER
PHLDA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHLDA2-001
ENSP00000319231
ENST00000314222
Q53GA4 [Direct mapping]
Pleckstrin homology-like domain family A member 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001890 [placenta development]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0009887 [organ morphogenesis]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0030334 [regulation of cell migration]
GO:0045995 [regulation of embryonic development]
GO:0070873 [regulation of glycogen metabolic process]
Show all
 152 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.