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SPRR2E

GENERAL INFORMATION

Gene name

 SPRR2E

Gene description

 Small proline-rich protein 2E

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin, tonsil)
GTEx:Tissue enhanced (esophagus, skin)
FANTOM5:Group enriched (esophagus, tonsil, cervix, uterine)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil, cervix, uterine)

GENE INFORMATION

Gene name

 SPRR2E

Synonyms

Description

 Small proline-rich protein 2E (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153093135 - 153106184

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000203785 (version 83.38)

Entrez gene

 6704

UniProt

 P22531 (UniProt - Evidence at transcript level)

neXtProt

 NX_P22531

Antibodypedia

 SPRR2E antibodies

PROTEIN BROWSER
SPRR2E-001
SPRR2E-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPRR2E-001
ENSP00000357740
ENST00000368751
P22531 [Direct mapping]
Small proline-rich protein 2E
Show all
Predicted intracellular proteins
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
Show all
 72 aa
7.9 kDa 		No 0
SPRR2E-002
ENSP00000357739
ENST00000368750
P22531 [Direct mapping]
Small proline-rich protein 2E
Show all
Predicted intracellular proteins
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
Show all
 72 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.