Tissue expression of SMTNL1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SMTNL1
Gene description	Smoothelin-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION
Gene name	SMTNL1 (HGNC Symbol)
Synonyms	CHASM
Description	Smoothelin-like 1 (HGNC Symbol)
Entrez gene summary	SMTNL1, which is a member of the smoothelin (SMTN; MIM 602127) family, regulates contraction and relaxation of skeletal and smooth muscle fibers and mediates vascular adaptation to exercise (Wooldridge et al., 2008 [PubMed 18310078]).[supplied by OMIM, Dec 2010]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	57542641 - 57550274
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000214872 (version 83.38)
Entrez gene	219537
UniProt	A8MU46 (UniProt - Evidence at protein level)
neXtProt	NX_A8MU46
Antibodypedia	SMTNL1 antibodies

PROTEIN BROWSER

SMTNL1-001	SMTNL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMTNL1-001 ENSP00000432651 ENST00000527972	E9PPJ3 [Direct mapping] Smoothelin-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008157 [protein phosphatase 1 binding] GO:0014823 [response to activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0031430 [M band] GO:0031674 [I band] GO:0042493 [response to drug] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045907 [positive regulation of vasoconstriction] GO:0045908 [negative regulation of vasodilation] GO:0048644 [muscle organ morphogenesis] Show all	494 aa 53 kDa	No	0
SMTNL1-201 ENSP00000382108 ENST00000399154	A8MU46 [Direct mapping] Smoothelin-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0031430 [M band] GO:0031674 [I band] GO:0043292 [contractile fiber] GO:0045907 [positive regulation of vasoconstriction] GO:0045908 [negative regulation of vasodilation] Show all	457 aa 49 kDa	No	0