Tissue expression of ERVW-1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ERVW-1
Gene description	Endogenous retrovirus group W, member 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (placenta)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION
Gene name	ERVW-1 (HGNC Symbol)
Synonyms	ERVWE1, HERV-7q, HERV-W, HERV-W-ENV, HERVW
Description	Endogenous retrovirus group W, member 1 (HGNC Symbol)
Entrez gene summary	Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Chromosome	7
Cytoband	q21.2
Chromosome location (bp)	92468380 - 92477986
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000242950 (version 83.38)
Entrez gene	30816
UniProt	Q9UQF0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQF0
Antibodypedia	ERVW-1 antibodies

PROTEIN BROWSER

ERVW-1-001	ERVW-1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERVW-1-001 ENSP00000419945 ENST00000493463	Q9UQF0 [Direct mapping] Syncytin-1 Surface protein Transmembrane protein D0EYG5 [Target identity:100%; Query identity:100%] Syncytin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0006949 [syncytium formation] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0019031 [viral envelope] Show all	538 aa 59.9 kDa	Yes	2
ERVW-1-002 ENSP00000474984 ENST00000603053	Q9UQF0 [Direct mapping] Syncytin-1 Surface protein Transmembrane protein D0EYG5 [Target identity:100%; Query identity:100%] Syncytin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0006949 [syncytium formation] GO:0009653 [anatomical structure morphogenesis] GO:0016021 [integral component of membrane] GO:0019031 [viral envelope] Show all	538 aa 59.9 kDa	Yes	2