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SPECC1L-ADORA2A

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GENERAL INFORMATION

Gene name

 SPECC1L-ADORA2A

Gene description

 SPECC1L-ADORA2A readthrough (NMD candidate)

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (SK-BR-3, U-266/84, U-698)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-BR-3, U-266/84, U-698)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SPECC1L-ADORA2A

Synonyms

Description

 SPECC1L-ADORA2A readthrough (NMD candidate) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Chromosome

 22

Cytoband

 q11.23

Chromosome location (bp)

 24270898 - 24442356

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000258555 (version 83.38)

Entrez gene

 135

UniProt

 P29274 (UniProt - Evidence at protein level)

neXtProt

 NX_P29274

Antibodypedia

 SPECC1L-ADORA2A antibodies

PROTEIN BROWSER
SPECC1L-ADORA2A-201
SPECC1L-ADORA2A-202
SPECC1L-ADORA2A-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPECC1L-ADORA2A-201
ENSP00000480012
ENST00000610595
P29274 [Direct mapping]
Adenosine receptor A2a
X5DNB4 [Target identity:100%; Query identity:100%]
Adenosine receptor A2
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007417 [central nervous system development]
GO:0007596 [blood coagulation]
GO:0007600 [sensory perception]
GO:0008015 [blood circulation]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0042802 [identical protein binding]
GO:0044267 [cellular protein metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 412 aa
44.7 kDa 		No 7
SPECC1L-ADORA2A-202
ENSP00000483102
ENST00000611543
P29274 [Direct mapping]
Adenosine receptor A2a
X5DNB4 [Target identity:100%; Query identity:100%]
Adenosine receptor A2
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007417 [central nervous system development]
GO:0007596 [blood coagulation]
GO:0007600 [sensory perception]
GO:0008015 [blood circulation]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0042802 [identical protein binding]
GO:0044267 [cellular protein metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 412 aa
44.7 kDa 		No 7
SPECC1L-ADORA2A-203
ENSP00000481552
ENST00000618076
P29274 [Direct mapping]
Adenosine receptor A2a
X5DNB4 [Target identity:100%; Query identity:100%]
Adenosine receptor A2
Show all
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0006909 [phagocytosis]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007417 [central nervous system development]
GO:0007596 [blood coagulation]
GO:0007600 [sensory perception]
GO:0008015 [blood circulation]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0042802 [identical protein binding]
GO:0044267 [cellular protein metabolic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 412 aa
44.7 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.