Tissue expression of ANXA8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ANXA8
Gene description	Annexin A8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (skin, esophagus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skin, esophagus)

GENE INFORMATION
Gene name	ANXA8 (HGNC Symbol)
Synonyms	ANX8
Description	Annexin A8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q11.22
Chromosome location (bp)	47460162 - 47484158
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000265190 (version 83.38)
Entrez gene	653145
UniProt	P13928 (UniProt - Evidence at protein level)
neXtProt	NX_P13928
Antibodypedia	ANXA8 antibodies

PROTEIN BROWSER

ANXA8-001	ANXA8-002	ANXA8-004	ANXA8-201	ANXA8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANXA8-001 ENSP00000462880 ENST00000585281	P13928 [Direct mapping] Annexin A8 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007032 [endosome organization] GO:0007596 [blood coagulation] GO:0016197 [endosomal transport] GO:0031902 [late endosome membrane] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0051015 [actin filament binding] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900138 [negative regulation of phospholipase A2 activity] Show all	327 aa 36.9 kDa	No	0
ANXA8-002 ENSP00000464486 ENST00000583874	A0A075B765 [Direct mapping] Annexin Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	276 aa 30.7 kDa	No	0
ANXA8-004 ENSP00000462181 ENST00000583448	A0A075B748 [Direct mapping] Annexin A8 Show all	Predicted intracellular proteins Show all		21 aa 2.4 kDa	No	0
ANXA8-201 ENSP00000463091 ENST00000583911	P13928 [Direct mapping] Annexin A8 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007032 [endosome organization] GO:0007596 [blood coagulation] GO:0016197 [endosomal transport] GO:0031902 [late endosome membrane] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0051015 [actin filament binding] GO:1900004 [negative regulation of serine-type endopeptidase activity] GO:1900138 [negative regulation of phospholipase A2 activity] Show all	265 aa 30 kDa	No	0
ANXA8-202 ENSP00000478026 ENST00000611843	A0A087WTN9 [Direct mapping] Annexin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] Show all	365 aa 40.7 kDa	No	0