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Malignant cells showed weak to moderate nuclear or nucleolar staining. Occasional cases of colorectal, testis and urothelial cancers exhibited strong positivity. Renal cancers were negative.
GENE INFORMATION
Gene name
KLF14 (HGNC Symbol)
Synonyms
BTEB5
Description
Kruppel-like factor 14 (HGNC Symbol)
Entrez gene summary
This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]