Tissue expression of CCL16 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CCL16
Gene description	Chemokine (C-C motif) ligand 16
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	CCL16 (HGNC Symbol)
Synonyms	CKb12, HCC-4, LCC-1, LEC, LMC, Mtn-1, NCC-4, SCYA16, SCYL4
Description	Chemokine (C-C motif) ligand 16 (HGNC Symbol)
Entrez gene summary	This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	35976493 - 35981496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000275152 (version 83.38)
Entrez gene	6360
UniProt	O15467 (UniProt - Evidence at protein level)
neXtProt	NX_O15467
Antibodypedia	CCL16 antibodies

PROTEIN BROWSER

CCL16-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCL16-001 ENSP00000478024 ENST00000611905	O15467 [Direct mapping] C-C motif chemokine 16 Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0002548 [monocyte chemotaxis] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007154 [cell communication] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0008009 [chemokine activity] GO:0030593 [neutrophil chemotaxis] GO:0042056 [chemoattractant activity] GO:0043547 [positive regulation of GTPase activity] GO:0048020 [CCR chemokine receptor binding] GO:0048245 [eosinophil chemotaxis] GO:0048247 [lymphocyte chemotaxis] GO:0050729 [positive regulation of inflammatory response] GO:0050918 [positive chemotaxis] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071346 [cellular response to interferon-gamma] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] Show all	120 aa 13.6 kDa	Yes	0