THE HUMAN PROTEIN ATLAS BLOG

Proteomics methods promote understanding autoimmunity in neurodegenerative disorders

2017-10-09
Affinity proteomics blood samples Malaria Multiple Sclerosis narcolepsy Neurodegenerative disorders Plasma Plasma Profilling psychosis

Arash Zandian's doctoral thesis defense at SciLifeLab, KTH

The last decades of technical development and availability of protein and peptide microarrays have enabled large-scale profiling of antibodies and precise determination of their specificities through epitope mapping. This has enabled characterization of the human immune response and the produced antibodies. Beside exploring the auto-antibody repertoire, this approach also identifies key autoantigens targeted by the antibodies in e.g. neurodegenerative disorders...Read more


Ovarian Cancer Awareness Month

2017-09-29
Cancer Immunohistochemistry Life Science Ovarian cancer awareness Pathology Atlas Plasma Profilling TCGA tissue

Figure 1. Immunohistochemical staining of EPCAM using antibody CAB055098 shows differential expression, both high (left panel) and low (right panel) in samples from ovarian cancer patients.

In this week's Pathology Atlas blog post, we highlight genes with prognostic association to ovarian cancer , as September is National Ovarian Cancer Awareness Month in the US. Ovarian cancer is the fifth most frequent cause of cancer death in women, and 50% of all ovarian cancers are diagnosed in women older than 65 years of age.

Epithelial ovarian carcinoma is one of the most common gynecologic malignancy. There are five subtypes of epithelial ovarian carcinoma, of which high-grade serous carcinoma is the most common...Read more


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