THE HUMAN PROTEIN ATLAS BLOG

CD44 as a marker of renal cancer

2017-03-31
Cancer Image of the week Immunohistochemistry Pathology Atlas Renal Cell Carcinoma

Renal cell cancer is a relatively common form of human cancer. Tumors develop in the kidney and have a tendency to grow into renal veins and metastasize to distant organs without the spread to regional lymph nodes as is common for many other tumor types.

This particular case shows a papillary form of renal cell cancer that grows with papillary excrescences into cyst formations and with areas of necrosis. The tumor has been stained with an antibody (HPA005785) that recognizes the CD44 protein.

CD44 is a cell-surface glycoprotein and a receptor for hyaluronic acid that is involved in cell-cell interactions, cell adhesion and migration...Read more


Cancer biomarkers identified

2017-01-23
Biomarkers Breast Cancer Cancer Immunocytochemistry Renal Cell Carcinoma

Gabriela Gremel, involved in both studies on cancer biomarkers

In two recent publications the group of Fredrik PontÚn in Uppsala has identified two very strong, independent biomarkers for the prognostic stratification of breast cancer and renal cell carcinoma.

Renal cell carcinoma is the most common type of cancer affecting the kidney and there is an unmet clinical need for better prognostic and diagnostic tools for it. Diagnosis and subtyping of renal cell carcinoma are achieved through the morphological analysis of tumor sections. The application of immunohistochemistry can reveal important additional clues during the diagnostic work-up...Read more


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