Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence HPA evidence UniProt evidence MS evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location RNA tissue category RNA TS RNA TS TPM TPM max in non-specific ACE ACE1, CD143, DCP1 ENSG00000159640 Angiotensin I converting enzyme 17 63477061-63498380 Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002426, CAB002921, HPA029298, HPA069790 Supported Approved Vesicles Tissue enhanced 0 duodenum: 183.8;small intestine: 297.5 testis: 83.7 ACHE YT ENSG00000087085 Acetylcholinesterase (Yt blood group) 7 100889994-100896974 Blood group antigen proteins, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA019704, HPA027098 Approved Golgi apparatus
Vesicles Tissue enhanced 0 skeletal muscle: 58.5 cerebral cortex: 14.1 ALPPL2 ENSG00000163286 Alkaline phosphatase, placental-like 2 2 232406843-232410714 Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level Evidence at protein level CAB020698, HPA038764, HPA038765, HPA051699 Supported Approved Plasma membrane Tissue enhanced 0 cervix, uterine: 1.1;fallopian tube: 1.9 lung: 0.7 AMY2A AMY2 ENSG00000243480 Amylase, alpha 2A (pancreatic) 1 103616811-103625780 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA045394, HPA045399, CAB045960, HPA046980 Supported Tissue enriched 313 pancreas: 31311.3 ovary: 100.1 AOC3 HPAO, VAP-1, VAP1 ENSG00000131471 Amine oxidase, copper containing 3 17 42851184-42858130 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA000980, CAB025797 Supported Approved Golgi apparatus
Cytosol Tissue enhanced 0 adipose tissue: 449.0 smooth muscle: 203.0 BCHE CHE1, CHE2, E1 ENSG00000114200 Butyrylcholinesterase 3 165772904-165837472 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001560 Supported Tissue enhanced 0 liver: 264.1 endometrium: 66.8 BGLAP OCN ENSG00000242252 Bone gamma-carboxyglutamate (gla) protein 1 156241962-156243321 FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Mixed skin: 2.1 BLVRB FLR, SDR43U1 ENSG00000090013 Biliverdin reductase B 19 40447789-40465840 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA041698, HPA041937 Supported Supported Nucleoplasm
Plasma membrane
Cytosol Expressed in all bone marrow: 339.1 C3 ARMD9, C3a, C3b, CPAMD1 ENSG00000125730 Complement component 3 19 6677704-6730562 Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003563, CAB004209, HPA020432 Supported Expressed in all liver: 2484.3 C4A C4, C4A2, C4A3, C4A4, C4A6, C4B, C4S, CO4, CPAMD2, RG ENSG00000244731 Complement component 4A (Rodgers blood group) 6 31982024-32002681 Blood group antigen proteins, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB009811, CAB032603, HPA046356, HPA048287, HPA050103 Approved Tissue enhanced 0 liver: 46.2 thyroid gland: 28.2 C4B C4B1, C4B3, C4F, CH, CO4, CPAMD3 ENSG00000224389 Complement component 4B (Chido blood group) 6 32014762-32035418 Blood group antigen proteins, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA046356, HPA048287, HPA050103 Approved Tissue enhanced 0 adrenal gland: 59.8;liver: 65.6 kidney: 18.4 C5 C5a, C5b, CPAMD4 ENSG00000106804 Complement component 5 9 120952335-121050276 Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA029339 Uncertain Tissue enriched 21 liver: 225.4 lung: 10.5 CACNA2D1 CACNA2, CACNL2A, LINC01112, lncRNA-N3, MHS3 ENSG00000153956 Calcium channel, voltage-dependent, alpha 2/delta subunit 1 7 81946444-82443798 FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA008213, HPA008621 Supported Mixed cerebral cortex: 35.5 CARTPT CART ENSG00000164326 CART prepropeptide 5 71719163-71721048 FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA046278 Uncertain Tissue enriched 8 adrenal gland: 133.2 cerebral cortex: 17.4 CCL2 GDCF-2, HC11, MCAF, MCP-1, MCP1, MGC9434, SCYA2, SMC-CF ENSG00000108691 Chemokine (C-C motif) ligand 2 17 34255218-34257203 Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB013676, HPA019163 Approved Approved Golgi apparatus
Vesicles Expressed in all gallbladder: 412.4 CD2 SRBC ENSG00000116824 CD2 molecule 1 116754385-116769228 CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002430, HPA003883 Supported Tissue enhanced 0 lymph node: 132.9 tonsil: 73.5 CD3D T3D ENSG00000167286 CD3d molecule, delta (CD3-TCR complex) 11 118338954-118342744 CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB013055 Supported Tissue enhanced 0 lymph node: 202.6;tonsil: 124.1 appendix: 90.4 CD4 ENSG00000010610 CD4 molecule 12 6786858-6820808 CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000011, HPA004252, HPA004472, CAB068180 Supported Supported Plasma membrane Tissue enhanced 0 parathyroid gland: 538.7 spleen: 224.0 CD44 CD44R, CSPG8, HCELL, IN, MC56, MDU2, MDU3, MIC4, Pgp1 ENSG00000026508 CD44 molecule (Indian blood group) 11 35138870-35232402 Blood group antigen proteins, Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000112, CAB000316, HPA005785 Supported Validated Golgi apparatus
Plasma membrane Expressed in all skin: 505.8 CD80 B7-1, B7.1, CD28LG, CD28LG1 ENSG00000121594 CD80 molecule 3 119524293-119559602 CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB025368, HPA050092 Supported Tissue enhanced 0 appendix: 7.4;lymph node: 6.8;tonsil: 6.1 spleen: 4.6 CD86 B7-2, B7.2, CD28LG2 ENSG00000114013 CD86 molecule 3 122055366-122121139 CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB004319 Uncertain Tissue enhanced 0 appendix: 49.1 spleen: 32.9 CES1 CEH, CES1A1, CES1A2, CES2, HMSE, HMSE1, SES1 ENSG00000198848 Carboxylesterase 1 16 55802851-55833337 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA012023, HPA046717 Supported Validated Endoplasmic reticulum Group enriched 7 gallbladder: 400.5;liver: 1099.6;lung: 229.6 adipose tissue: 79.7 CHRNA2 ENSG00000120903 Cholinergic receptor, nicotinic, alpha 2 (neuronal) 8 27459761-27479883 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enriched 20 prostate: 43.0 breast: 2.1 CKMT1A CKMT1 ENSG00000223572 Creatine kinase, mitochondrial 1A 15 43692886-43699222 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA043491 Uncertain Mixed rectum: 75.0 CKMT1B CKMT, CKMT1, UMTCK ENSG00000237289 Creatine kinase, mitochondrial 1B 15 43593054-43604901 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA043491 Uncertain Tissue enhanced 0 colon: 79.4;rectum: 69.8 duodenum: 64.7 CSF2RA CD116, CSF2R ENSG00000198223 Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) X 1268800-1310381 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB016148 Uncertain Tissue enhanced 0 placenta: 93.5 appendix: 36.4 CTLA4 CD, CD152, CD28, CELIAC3, GSE, ICOS, IDDM12 ENSG00000163599 Cytotoxic T-lymphocyte-associated protein 4 2 203867786-203873960 CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Tissue enhanced 0 appendix: 24.2;lymph node: 32.3 tonsil: 15.9 CYP17A1 CPT7, CYP17, P450C17, S17AH ENSG00000148795 Cytochrome P450, family 17, subfamily A, polypeptide 1 10 102830531-102837533 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA048533 Supported Tissue enriched 25 adrenal gland: 4500.7 testis: 180.3 DBH DBM ENSG00000123454 Dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9 133636360-133659344 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002130, HPA005960, HPA070789 Supported Supported Vesicles Tissue enriched 12 adrenal gland: 358.5 epididymis: 30.6 DDR2 NTRKR3, TKT, TYRO10 ENSG00000162733 Discoidin domain receptor tyrosine kinase 2 1 162631373-162787400 CD markers, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA070112 Supported Plasma membrane
Actin filaments Mixed adrenal gland: 94.0 DPEP1 ENSG00000015413 Dipeptidase 1 (renal) 16 89613308-89638456 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA009426, HPA012783 Supported Approved Nucleus
Cell Junctions Tissue enhanced 0 kidney: 262.3;small intestine: 426.5 pancreas: 92.8 DPP4 ADCP2, CD26, DPPIV ENSG00000197635 Dipeptidyl-peptidase 4 2 161992241-162074542 CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB045970 Supported Tissue enhanced 0 parathyroid gland: 542.0 placenta: 167.8 EDNRB ETB, HSCR, HSCR2 ENSG00000136160 Endothelin receptor type B 13 77895481-77919768 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB017842, HPA027546 Approved Approved Plasma membrane
Cytosol Tissue enhanced 0 placenta: 178.8 cerebral cortex: 89.1 EGFR ERBB, ERBB1 ENSG00000146648 Epidermal growth factor receptor 7 55019021-55256620 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000035, HPA001200, HPA018530, CAB068186, CAB073534 Supported Validated Plasma membrane Tissue enhanced 0 placenta: 97.3 skin: 58.9 ELANE ELA2, HLE, HNE, NE ENSG00000197561 Elastase, neutrophil expressed 19 851014-856247 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB015409, HPA066836 Supported Tissue enriched 320 bone marrow: 1202.2 skin: 3.7 F10 ENSG00000126218 Coagulation factor X 13 113122814-113149529 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enhanced 0 liver: 68.0 cervix: 51.6 F11 FXI ENSG00000088926 Coagulation factor XI 4 186265945-186288806 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA039808 Approved Vesicles Tissue enhanced 0 liver: 179.3 kidney: 44.4 F2 ENSG00000180210 Coagulation factor II (thrombin) 11 46719180-46739506 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016780, CAB018650, HPA051476, HPA054698 Supported Tissue enriched 1471 liver: 627.1 testis: 0.4 F2R CF2R, PAR-1, PAR1, TR ENSG00000181104 Coagulation factor II (thrombin) receptor 5 76716043-76735781 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB008973, CAB012962 Approved Expressed in all spleen: 95.4 F5 ENSG00000198734 Coagulation factor V (proaccelerin, labile factor) 1 169514166-169586588 Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA002036 Uncertain Approved Golgi apparatus Group enriched 11 gallbladder: 28.5;liver: 93.7;placenta: 67.7 fallopian tube: 5.8 F7 ENSG00000057593 Coagulation factor VII (serum prothrombin conversion accelerator) 13 113105788-113120681 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enriched 44 liver: 65.2 testis: 1.4 F8 DXS1253E, F8C, FVIII, HEMA ENSG00000185010 Coagulation factor VIII, procoagulant component X 154835788-155026940 Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB018777 Supported Expressed in all lung: 23.4 F9 FIX ENSG00000101981 Coagulation factor IX X 139530758-139563458 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enriched 2286 liver: 364.7 kidney: 0.1 FCGR1B CD64b ENSG00000198019 Fc fragment of IgG, high affinity Ib, receptor (CD64) 1 121087345-121096310 FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at transcript level Evidence at transcript level Evidence at transcript level Tissue enhanced 0 appendix: 28.1;epididymis: 61.7 placenta: 17.2 FCGR3A CD16, CD16a, FCG3, FCGR3 ENSG00000203747 Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1 161541759-161550737 CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB032435, HPA055431 Supported Expressed in all spleen: 427.3 FGA ENSG00000171560 Fibrinogen alpha chain 4 154583126-154590766 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB016776, HPA051370, HPA064755 Supported Tissue enriched 246 liver: 9252.8 stomach: 37.6 FGFR1 BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM ENSG00000077782 Fibroblast growth factor receptor 1 8 38411138-38468834 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB033614, HPA056402, HPA076274 Approved Approved Nucleoli Expressed in all gallbladder: 109.6 FGFR2 BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25 ENSG00000066468 Fibroblast growth factor receptor 2 10 121478334-121598458 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB010886, HPA035305, HPA056562 Uncertain Approved Vesicles Mixed skin: 97.5 FGFR3 ACH, CD333, CEK2, JTK4 ENSG00000068078 Fibroblast growth factor receptor 3 4 1793307-1808872 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB004231, HPA067204 Supported Supported Endoplasmic reticulum Tissue enriched 7 skin: 334.6 cerebral cortex: 49.7 FGFR4 CD334, JTK2 ENSG00000160867 Fibroblast growth factor receptor 4 5 177086886-177098144 Cancer-related genes, CD markers, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB005196, HPA027273, HPA027369, HPA028251 Approved Tissue enhanced 0 lung: 39.1 duodenum: 22.0 FLT1 FLT, VEGFR1 ENSG00000102755 Fms-related tyrosine kinase 1 13 28300344-28495128 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA011740, HPA014290, CAB068189, CAB068190 Supported Supported Plasma membrane
Actin filaments Tissue enriched 8 placenta: 617.5 thyroid gland: 81.7 FLT4 PCL, VEGFR3 ENSG00000037280 Fms-related tyrosine kinase 4 5 180601506-180649624 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000099 Supported Nuclear speckles
Plasma membrane
Cell Junctions Mixed spleen: 18.6 FN1 CIG, FINC, GFND2, LETS, MSF ENSG00000115414 Fibronectin 1 2 215360440-215436172 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000126, HPA027066 Supported Tissue enhanced 0 placenta: 4245.7 lung: 1168.8 FSHR FSHRO, LGR1, ODG1 ENSG00000170820 Follicle stimulating hormone receptor 2 48962157-49154537 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Group enriched 9 ovary: 2.5;testis: 4.3 heart muscle: 0.3 GABBR1 GPRC3A, hGB1a ENSG00000204681 Gamma-aminobutyric acid (GABA) B receptor, 1 6 29555629-29633976 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA050483, HPA058459 Uncertain Uncertain Centrosome Tissue enhanced 0 cerebral cortex: 20.9 spleen: 13.3 GABRA1 EJM5 ENSG00000022355 Gamma-aminobutyric acid (GABA) A receptor, alpha 1 5 161847191-161899981 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB022502, HPA055746 Supported Tissue enriched 44 cerebral cortex: 109.1 adrenal gland: 2.4 GABRA2 ENSG00000151834 Gamma-aminobutyric acid (GABA) A receptor, alpha 2 4 46248427-46475230 FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at transcript level Evidence at transcript level Evidence at protein level Tissue enriched 6 cerebral cortex: 74.5 epididymis: 13.3 GABRA5 ENSG00000186297 Gamma-aminobutyric acid (GABA) A receptor, alpha 5 15 26866363-26949207 FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA077031 Supported Cell Junctions Tissue enriched 43 cerebral cortex: 82.0 esophagus: 1.8 GABRG3 ENSG00000182256 Gamma-aminobutyric acid (GABA) A receptor, gamma 3 15 26971282-27541991 FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level HPA054010 Supported Tissue enhanced 0 prostate: 10.6;testis: 16.4 cerebral cortex: 4.2 GABRP ENSG00000094755 Gamma-aminobutyric acid (GABA) A receptor, pi 5 170763350-170814047 FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at transcript level CAB014883 Uncertain Expressed in all breast: 186.6 GANAB G2AN, GluII, KIAA0088 ENSG00000089597 Glucosidase, alpha; neutral AB 11 62624826-62646726 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA026874, HPA061426 Supported Approved Nuclear membrane
Endoplasmic reticulum
Cytosol Expressed in all parathyroid gland: 289.5 GCGR GGR ENSG00000215644 Glucagon receptor 17 81804132-81814013 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA071228 Approved Golgi apparatus Group enriched 7 adrenal gland: 6.6;kidney: 8.5;liver: 20.9;parathyroid gland: 9.4 skin: 1.6 GHRHR ENSG00000106128 Growth hormone releasing hormone receptor 7 30938669-30993254 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level No evidence Evidence at protein level Not detected adrenal gland: 0.5 GLRB ENSG00000109738 Glycine receptor, beta 4 157076057-157172090 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA052363 Approved Tissue enhanced 0 cerebral cortex: 62.2;parathyroid gland: 62.0 cervix: 14.0 GRIN2B GluN2B, NMDAR2B ENSG00000273079 Glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12 13537337-13981957 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA069762 Approved Tissue enriched 25 cerebral cortex: 13.2 adipose tissue: 0.5 GRM5 GPRC1E, mGlu5, MGLUR5, PPP1R86 ENSG00000168959 Glutamate receptor, metabotropic 5 11 88504576-89065945 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enriched 9 cerebral cortex: 27.3 testis: 3.1 ICAM1 BB2, CD54 ENSG00000090339 Intercellular adhesion molecule 1 19 10270835-10286615 Cancer-related genes, Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002126, CAB002142, HPA004877 Supported Uncertain Plasma membrane
Cytosol Expressed in all lung: 256.0 IDE ENSG00000119912 Insulin-degrading enzyme 10 92451684-92574076 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA063478 Approved Expressed in all skin: 63.5 IFNAR1 IFNAR, IFRC ENSG00000142166 Interferon (alpha, beta and omega) receptor 1 21 33324477-33359862 Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA018015, HPA029226 Approved Approved Cytosol Expressed in all parathyroid gland: 60.2 IFNG ENSG00000111537 Interferon, gamma 12 68154768-68159747 Cancer-related genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level CAB010344 Approved Tissue enhanced 0 appendix: 4.9;bone marrow: 7.6;lymph node: 8.0 lung: 2.5 IFNGR1 CD119, IFNGR ENSG00000027697 Interferon gamma receptor 1 6 137197484-137219449 CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA029213, HPA063871 Approved Supported Endoplasmic reticulum
Vesicles
Plasma membrane Expressed in all spleen: 225.2 IL11RA ENSG00000137070 Interleukin 11 receptor, alpha 9 34650702-34661892 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA013162, CAB032830, HPA036652 Supported Expressed in all skin: 72.6 IL17A CTLA8, IL-17, IL-17A, IL17 ENSG00000112115 Interleukin 17A 6 52186387-52190638 Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level HPA052258 Uncertain Tissue enhanced 0 appendix: 1.0;tonsil: 1.4;urinary bladder: 1.6 gallbladder: 0.3 IL1R1 CD121A, D2S1473, IL1R, IL1RA ENSG00000115594 Interleukin 1 receptor, type I 2 102064544-102179874 Cancer-related genes, CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001237, HPA005823, CAB007779, HPA029560 Approved Validated Vesicles Expressed in all cervix: 244.6 IL2RB CD122, IL15RB ENSG00000100385 Interleukin 2 receptor, beta 22 37125838-37175054 Cancer-related genes, CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA062657 Supported Tissue enhanced 0 spleen: 68.3 placenta: 52.4 IL3RA CD123 ENSG00000185291 Interleukin 3 receptor, alpha (low affinity) X 1336616-1382689 CD markers, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003539, CAB018374 Approved Expressed in all lung: 33.8 IL5 EDF, IL-5, TRF ENSG00000113525 Interleukin 5 5 132541444-132556838 Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level CAB010304 Approved Tissue enriched 9 testis: 9.7 epididymis: 1.1 IL6 BSF2, HGF, HSF, IFNB2, IL-6 ENSG00000136244 Interleukin 6 7 22725884-22732002 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB023406, CAB072821 Supported Approved Vesicles Tissue enhanced 0 adipose tissue: 135.4 urinary bladder: 76.8 IL6R CD126 ENSG00000160712 Interleukin 6 receptor 1 154405193-154469450 Cancer-related genes, Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Expressed in all appendix: 34.4 ITGA4 CD49D ENSG00000115232 Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 2 181457202-181536187 Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA064041 Approved Golgi apparatus
Vesicles Tissue enhanced 0 spleen: 68.6 appendix: 51.2 ITGAL CD11A, LFA-1 ENSG00000005844 Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 16 30472658-30523185 CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025011 Supported Tissue enhanced 0 lymph node: 80.1;spleen: 82.2 appendix: 54.3 ITGB1 CD29, FNRB, GPIIA, MDF2, MSK12 ENSG00000150093 Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 10 32900319-33005792 Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB003434 Approved Supported Endoplasmic reticulum
Plasma membrane
Focal adhesion sites Expressed in all smooth muscle: 1058.2 ITGB3 CD61, GP3A, GPIIIa ENSG00000259207 Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 17 47253846-47311816 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA027852 Supported Tissue enhanced 0 thyroid gland: 95.1 smooth muscle: 36.3 ITGB7 ENSG00000139626 Integrin, beta 7 12 53191318-53207307 Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA042277 Approved Plasma membrane
Cytosol Mixed spleen: 32.8 KCNN4 hIKCa1, hKCa4, hSK4, IK, KCa3.1 ENSG00000104783 Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 19 43766533-43781257 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters, Voltage-gated ion channels Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA053841, HPA059622 Approved Tissue enhanced 0 salivary gland: 74.3 stomach: 37.1 KLKB1 KLK3 ENSG00000164344 Kallikrein B, plasma (Fletcher factor) 1 4 186208979-186258471 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enriched 45 liver: 154.2 kidney: 3.4 LHCGR HHG, LCGR, LGR2, LHR, ULG5 ENSG00000138039 Luteinizing hormone/choriogonadotropin receptor 2 48686775-48755730 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB009814 Uncertain Group enriched 5 adipose tissue: 1.3;adrenal gland: 1.1;ovary: 1.5;testis: 4.3;thyroid gland: 1.1 breast: 0.3 LIPF HGL, HLAL ENSG00000182333 Lipase, gastric 10 88664441-88678814 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA045930 Supported Tissue enriched 82 stomach: 21780.0 duodenum: 267.0 LPL LIPD ENSG00000175445 Lipoprotein lipase 8 19901717-19967258 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA048749 Approved Vesicles Tissue enhanced 0 adipose tissue: 974.6 parathyroid gland: 224.5 M6PR ENSG00000003056 Mannose-6-phosphate receptor (cation dependent) 12 8940363-8949955 FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB034464, HPA040445 Approved Expressed in all spleen: 178.5 MET DFNB97, HGFR, RCCP2 ENSG00000105976 MET proto-oncogene, receptor tyrosine kinase 7 116672390-116798386 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB005282, CAB018577, HPA055607 Uncertain Supported Plasma membrane
Cytosol Mixed placenta: 38.7 MMP1 CLG ENSG00000196611 Matrix metallopeptidase 1 11 102789920-102798160 Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004920 Supported Vesicles Tissue enhanced 0 appendix: 39.7;gallbladder: 126.6 urinary bladder: 30.2 MMP10 STMY2 ENSG00000166670 Matrix metallopeptidase 10 11 102770503-102780628 Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002159 Uncertain Approved Plasma membrane
Cytosol Tissue enriched 39 endometrium: 443.1 appendix: 11.3 MMP11 STMY3 ENSG00000099953 Matrix metallopeptidase 11 22 23768226-23784316 Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB002593, HPA068864 Approved Group enriched 9 cervix, uterine: 30.9;endometrium: 122.3;placenta: 27.9 smooth muscle: 6.4 MMP12 HME ENSG00000262406 Matrix metallopeptidase 12 11 102862736-102875034 Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enhanced 0 appendix: 55.9;urinary bladder: 29.8 tonsil: 17.9 MMP13 CLG3 ENSG00000137745 Matrix metallopeptidase 13 11 102942995-102955734 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enhanced 0 lung: 1.5;urinary bladder: 1.4 testis: 0.3 MMP14 MT1-MMP ENSG00000157227 Matrix metallopeptidase 14 (membrane-inserted) 14 22836557-22849027 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB009918, HPA051432 Approved Approved Intermediate filaments
Cytosol Mixed endometrium: 236.1 MMP17 MT4-MMP ENSG00000198598 Matrix metallopeptidase 17 (membrane-inserted) 12 131828393-131851783 Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Tissue enhanced 0 cerebral cortex: 24.1 skin: 8.2 MMP19 MMP18, RASI-1 ENSG00000123342 Matrix metallopeptidase 19 12 55835433-55842966 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA070804 Approved Endoplasmic reticulum
Vesicles Tissue enhanced 0 adipose tissue: 63.1;gallbladder: 97.5 placenta: 27.9 MMP2 CLG4, CLG4A, TBE-1 ENSG00000087245 Matrix metallopeptidase 2 16 55389700-55506691 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA001939, CAB002788 Approved Uncertain Vesicles
Cytosol Tissue enhanced 0 gallbladder: 1688.5 urinary bladder: 944.6 MMP20 ENSG00000137674 Matrix metallopeptidase 20 11 102576835-102625332 Disease related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Group enriched 5 breast: 1.2;testis: 1.1 tonsil: 0.2 MMP21 ENSG00000154485 Matrix metallopeptidase 21 10 125766453-125775821 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at transcript level Evidence at protein level Tissue enriched 27 epididymis: 58.2 ovary: 2.1 MMP25 MMP20, MMPL1, MT6-MMP ENSG00000008516 Matrix metallopeptidase 25 16 3046681-3060726 Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB025177 Uncertain Tissue enhanced 0 appendix: 23.9;bone marrow: 24.7;spleen: 21.1 adipose tissue: 6.3 MMP26 endometase, MGC126590, MGC126592 ENSG00000167346 Matrix metallopeptidase 26 11 4704927-4992429 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at transcript level Evidence at transcript level Evidence at transcript level Tissue enriched 64 endometrium: 23.8 prostate: 0.3 MMP27 ENSG00000137675 Matrix metallopeptidase 27 11 102691487-102705806 Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level HPA069097 Approved Group enriched 5 breast: 6.0;skin: 2.8 bone marrow: 0.8 MMP28 EPILYSIN, MM28, MMP-25, MMP-28 ENSG00000271447 Matrix metallopeptidase 28 17 35756249-35795707 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at transcript level Evidence at protein level Tissue enhanced 0 testis: 6.4 adipose tissue: 4.2 MMP3 STMY, STMY1 ENSG00000149968 Matrix metallopeptidase 3 11 102835801-102843803 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA007875 Uncertain Approved Vesicles Tissue enhanced 0 appendix: 26.9;endometrium: 58.7 urinary bladder: 9.2 MMP7 MPSL1, PUMP-1 ENSG00000137673 Matrix metallopeptidase 7 11 102520508-102530753 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB025869, HPA051358 Supported Approved Nucleoplasm
Vesicles Tissue enhanced 0 gallbladder: 824.4 breast: 201.5 MMP8 CLG1 ENSG00000118113 Matrix metallopeptidase 8 11 102711795-102727050 Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA021221, HPA022935 Supported Tissue enriched 103 bone marrow: 336.3 endometrium: 3.2 MMP9 CLG4B ENSG00000100985 Matrix metallopeptidase 9 20 46008908-46016561 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000348, HPA001238, HPA063909, CAB068199, CAB068200, CAB068201 Supported Approved Cytosol Tissue enhanced 0 bone marrow: 253.0;lymph node: 119.4 appendix: 85.4 MR1 HLALS ENSG00000153029 Major histocompatibility complex, class I-related 1 181033425-181061938 FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA048304 Supported Plasma membrane Mixed thyroid gland: 28.1 MTTP ABL, MTP ENSG00000138823 Microsomal triglyceride transfer protein 4 99563761-99623999 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA051170, HPA054862 Uncertain Approved Cytosol Group enriched 17 duodenum: 243.0;liver: 133.9;small intestine: 299.0 testis: 13.5 PCSK9 FH3, HCHOLA3, NARC-1 ENSG00000169174 Proprotein convertase subtilisin/kexin type 9 1 55039548-55064852 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enhanced 0 liver: 6.1;lung: 11.1 colon: 3.5 PDE7A HCP1 ENSG00000205268 Phosphodiesterase 7A 8 65717510-65842322 Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB018770, HPA027340 Approved Expressed in all lymph node: 69.7 PDGFRA CD140a, GAS9, PDGFR2 ENSG00000134853 Platelet-derived growth factor receptor, alpha polypeptide 4 54229097-54298247 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA004947, CAB018143 Supported Supported Nucleus
Plasma membrane
Cell Junctions Expressed in all ovary: 222.0 PDGFRB CD140b, JTK12, PDGFR, PDGFR1 ENSG00000113721 Platelet-derived growth factor receptor, beta polypeptide 5 150113837-150155872 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level CAB003842, CAB018144, HPA028499 Approved Approved Vesicles
Cytosol Mixed gallbladder: 194.6 PGF D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760 ENSG00000119630 Placental growth factor 14 74941834-74955784 Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at transcript level Evidence at protein level HPA041624 Approved Nucleoplasm
Mitochondria
Cytosol Tissue enhanced 0 placenta: 70.9;thyroid gland: 64.4 cervix: 29.9 PLA2G1B PLA2, PLA2A, PPLA2 ENSG00000170890 Phospholipase A2, group IB (pancreas) 12 120322111-120327789 Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB022329, HPA047822, HPA060803 Supported Validated Cytosol Tissue enriched 245 pancreas: 23848.8 ovary: 97.3 PLA2G2A PLA2B, PLA2L ENSG00000188257 Phospholipase A2, group IIA (platelets, synovial fluid) 1 19975431-19980416 Enzymes, FDA approved drug targets, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA015236 Supported Uncertain Nucleus
Nucleoli Tissue enhanced 0 colon: 111.4;rectum: 180.4;small intestine: 238.2 duodenum: 87.9 PLAT ENSG00000104368 Plasminogen activator, tissue 8 42175233-42207724 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003412, CAB009335 Supported Approved Actin filaments Tissue enhanced 0 parathyroid gland: 695.5 urinary bladder: 141.1 PLAU UPA, URK ENSG00000122861 Plasminogen activator, urokinase 10 73909177-73917497 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA008719 Approved Approved Plasma membrane
Cytosol Expressed in all appendix: 61.3 PLAUR CD87, UPAR, URKR ENSG00000011422 Plasminogen activator, urokinase receptor 19 43646095-43670547 Cancer-related genes, CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA050843, CAB073533 Uncertain Supported Plasma membrane Expressed in all bone marrow: 429.4 PLG ENSG00000122194 Plasminogen 6 160702238-160753315 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000668, CAB016678, HPA021602, HPA048823, HPA053770 Supported Uncertain Vesicles Tissue enriched 6 liver: 1748.3 kidney: 310.9 PNLIP PL ENSG00000175535 Pancreatic lipase 10 116545931-116567855 Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA062430, HPA062494 Supported Tissue enriched 324 pancreas: 93652.7 ovary: 288.6 PNP NP, PUNP ENSG00000198805 Purine nucleoside phosphorylase 14 20468954-20477094 Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001625 Supported Expressed in all epididymis: 686.0 PRLR ENSG00000113494 Prolactin receptor 5 35048756-35230589 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Tissue enhanced 0 placenta: 70.3 kidney: 32.9 PROC ENSG00000115718 Protein C (inactivator of coagulation factors Va and VIIIa) 2 127418427-127429246 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005550, CAB016721, CAB016792 Supported Tissue enriched 12 liver: 139.9 kidney: 12.0 PROS1 PROS ENSG00000184500 Protein S (alpha) 3 93873033-93974066 Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA007724, HPA023974 Supported Tissue enhanced 0 liver: 177.6 heart muscle: 75.3 PSMD1 P112, Rpn2, S1 ENSG00000173692 Proteasome 26S subunit, non-ATPase 1 2 231056864-231172827 FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB021092, HPA036736, HPA036737 Approved Approved Nucleoplasm
Actin filaments Expressed in all parathyroid gland: 200.6 PTGIR IP ENSG00000160013 Prostaglandin I2 (prostacyclin) receptor (IP) 19 46620468-46625118 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enhanced 0 lung: 14.0 appendix: 8.4 PTGS1 COX1, PGHS-1, PTGHS ENSG00000095303 Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 9 122370530-122395703 Cancer-related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA002834, CAB020315 Supported Supported Golgi apparatus
Vesicles Tissue enhanced 0 skin: 161.9 esophagus: 85.8 PTGS2 COX2 ENSG00000073756 Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1 186671791-186680427 Cancer-related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB000113, HPA001335 Approved Supported Endoplasmic reticulum Tissue enhanced 0 seminal vesicle: 178.8 cervix: 98.8 QPRT QPRTase ENSG00000103485 Quinolinate phosphoribosyltransferase 16 29679008-29698699 Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA011887 Approved Expressed in all kidney: 111.8 RAMP2 ENSG00000131477 Receptor (G protein-coupled) activity modifying protein 2 17 42758447-42763041 FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level HPA052020 Approved Vesicles Mixed lung: 179.1 REN ENSG00000143839 Renin 1 204154819-204166322 Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005131, CAB025903 Approved Tissue enhanced 0 kidney: 50.8;placenta: 21.0 endometrium: 8.9 RET CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51 ENSG00000165731 Ret proto-oncogene 10 43077027-43130351 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB002581, HPA008356, HPA008495, CAB018342 Approved Supported Supported Vesicles
Plasma membrane
Cytosol Tissue enriched 5 parathyroid gland: 146.8 adrenal gland: 29.2 RPL3 L3 ENSG00000100316 Ribosomal protein L3 22 39312882-39320389 FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Ribosomal proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA003365 Uncertain Supported Nucleoli
Cytosol Expressed in all ovary: 5662.0 SCN1B ENSG00000105711 Sodium channel, voltage gated, type I beta subunit 19 35030684-35040448 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Tissue enhanced 0 skeletal muscle: 133.8 cerebral cortex: 42.7 SCN3B HSA243396 ENSG00000166257 Sodium channel, voltage gated, type III beta subunit 11 123629187-123655244 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA042518 Approved Nuclear membrane
Cytokinetic bridge Tissue enriched 11 cerebral cortex: 132.5 adrenal gland: 11.6 SDHD PGL, PGL1 ENSG00000204370 Succinate dehydrogenase complex, subunit D, integral membrane protein 11 112086773-112120013 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA045727 Approved Expressed in all kidney: 303.5 SERPINB2 HsT1201, PAI2, PLANH2 ENSG00000197632 Serpin peptidase inhibitor, clade B (ovalbumin), member 2 18 63871692-63903890 Cancer-related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA015480 Supported Approved Golgi apparatus Group enriched 6 esophagus: 261.7;placenta: 69.7;skin: 106.0;tonsil: 75.5 bone marrow: 22.3 SERPINC1 AT3, ATIII, MGC22579 ENSG00000117601 Serpin peptidase inhibitor, clade C (antithrombin), member 1 1 173903804-173917378 Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001816, CAB016790, HPA024007 Supported Tissue enriched 675 liver: 2511.4 kidney: 3.7 SERPIND1 D22S673, HC-II, HC2, HCF2, HLS2 ENSG00000099937 Serpin peptidase inhibitor, clade D (heparin cofactor), member 1 22 20773879-20787720 Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB008639, HPA055767 Supported Approved Vesicles Tissue enriched 16 liver: 584.7 parathyroid gland: 35.5 SERPINE1 PAI, PAI1, PLANH1 ENSG00000106366 Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 7 101127089-101139266 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA050039 Approved Approved Cytosol Tissue enhanced 0 gallbladder: 581.0;placenta: 595.2 adipose tissue: 213.2 SIGMAR1 OPRS1, SR-BP1 ENSG00000147955 Sigma non-opioid intracellular receptor 1 9 34634722-34637809 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB013470, HPA018002, HPA024071 Approved Expressed in all liver: 67.8 SLC52A2 D15Ertd747e, FLJ11856, GPCR41, GPR172A, hRFT3, PAR1, RFVT2 ENSG00000185803 Solute carrier family 52 (riboflavin transporter), member 2 8 144354135-144361272 Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA063036 Approved Expressed in all placenta: 24.0 SLC8A1 NCX1 ENSG00000183023 Solute carrier family 8 (sodium/calcium exchanger), member 1 2 40097270-40611053 FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB022694, HPA070007 Uncertain Supported Nucleoplasm
Plasma membrane Tissue enhanced 0 heart muscle: 79.5 seminal vesicle: 38.2 TEK CD202b, TIE-2, TIE2, VMCM, VMCM1 ENSG00000120156 TEK tyrosine kinase, endothelial 9 27109141-27230175 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB010359, HPA073265 Approved Supported Plasma membrane
Microtubule organizing center Tissue enhanced 0 placenta: 65.3 lung: 42.7 TFPI EPI, LACI, TFI, TFPI1 ENSG00000003436 Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 2 187464230-187565760 Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA005575, CAB020842 Supported Approved Intermediate filaments
Cytosol Expressed in all placenta: 340.4 TNFSF11 CD254, ODF, OPGL, RANKL, TRANCE ENSG00000120659 Tumor necrosis factor (ligand) superfamily, member 11 13 42562736-42608013 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level CAB009193, HPA045142 Supported Tissue enhanced 0 lymph node: 17.6 appendix: 6.5 TOP1MT ENSG00000184428 Topoisomerase (DNA) I, mitochondrial 8 143304384-143359979 Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level HPA001915, HPA021542 Approved Supported Mitochondria Expressed in all testis: 41.2 TPO TPX ENSG00000115705 Thyroid peroxidase 2 1374223-1543711 Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level HPA007987, CAB009587 Supported Tissue enriched 101 thyroid gland: 1811.8 spleen: 17.9 TSHR LGR3 ENSG00000165409 Thyroid stimulating hormone receptor 14 80954989-81146302 Cancer-related genes, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level CAB000473 Approved Tissue enriched 277 thyroid gland: 443.8 lymph node: 1.6 VEGFA VEGF, VEGF-A, VPF ENSG00000112715 Vascular endothelial growth factor A 6 43770184-43786487 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB005429, CAB039240, HPA069116 Approved Expressed in all thyroid gland: 455.6 VEGFB VEGFL, VRF ENSG00000173511 Vascular endothelial growth factor B 11 64234538-64238793 Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level Expressed in all adipose tissue: 194.9 VKORC1 VKCFD2 ENSG00000167397 Vitamin K epoxide reductase complex, subunit 1 16 31090842-31095980 Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level Evidence at transcript level Evidence at protein level Evidence at protein level HPA042720 Approved Expressed in all liver: 141.1 VWF F8VWF ENSG00000110799 Von Willebrand factor 12 5948874-6124770 Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins Evidence at protein level Evidence at protein level Evidence at protein level Evidence at protein level CAB001694, HPA001815, HPA002082, CAB072874, CAB072875 Supported Mixed adipose tissue: 154.4