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FHL1

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GENERAL INFORMATION

Gene name

 FHL1

Gene description

 Four and a half LIM domains 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 28
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane.

RNA cell category

 Cell line enhanced (BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA001040
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

 Cytosol (supported)

Additional location

 Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA001040 A-431 Plasma membrane
Cytosol
HPA001040 U-2 OS Cytosol
HPA001040 U-251 MG Cytosol

GENE INFORMATION

Gene name

 FHL1 (HGNC Symbol)

Synonyms

 bA535K18.1, FHL1B, FLH1A, KYO-T, MGC111107, SLIM1, XMPMA

Description

 Four and a half LIM domains 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

Chromosome

 X

Cytoband

 q26.3

Chromosome location (bp)

 136146702 - 136211359

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000022267 (version 83.38)

Entrez gene

 2273

UniProt

 Q13642 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13642

Antibodypedia

 FHL1 antibodies

PROTEIN BROWSER
«
FHL1-001
FHL1-002
FHL1-003
FHL1-004
FHL1-006
FHL1-007
FHL1-008
FHL1-010
FHL1-011
FHL1-012
FHL1-013
FHL1-014
FHL1-015
FHL1-016
FHL1-017
FHL1-018
FHL1-019
FHL1-020
FHL1-021
FHL1-022
FHL1-023
FHL1-024
FHL1-025
FHL1-026
FHL1-027
FHL1-031
FHL1-201
FHL1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FHL1-001
ENSP00000359724
ENST00000370690
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-002
ENSP00000071281
ENST00000345434
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 323 aa
36.3 kDa 		No 0
FHL1-003
ENSP00000359710
ENST00000370676
Q5JXI2 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 210 aa
23.7 kDa 		No 0
FHL1-004
ENSP00000359717
ENST00000370683
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 296 aa
33.6 kDa 		No 0
FHL1-006
ENSP00000391779
ENST00000420362
Q5JXH8 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 204 aa
23.2 kDa 		No 0
FHL1-007
ENSP00000359708
ENST00000370674
Q5JXI8 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 257 aa
29.2 kDa 		No 0
FHL1-008
ENSP00000408038
ENST00000452016
Q5JXI3 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 207 aa
23.6 kDa 		No 0
FHL1-010
ENSP00000413798
ENST00000434885
Q5JXI3 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 207 aa
23.6 kDa 		No 0
FHL1-011
ENSP00000389920
ENST00000458357
Q5JXH9 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 155 aa
17.8 kDa 		No 0
FHL1-012
ENSP00000412642
ENST00000456445
Q5JXH7 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 205 aa
23.3 kDa 		No 0
FHL1-013
ENSP00000414604
ENST00000449474
Q5JXI0 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0008270 [zinc ion binding]
Show all
 141 aa
16.2 kDa 		No 0
FHL1-014
ENSP00000486439
ENST00000629039
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-015
ENSP00000485897
ENST00000630084
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-016
ENSP00000443333
ENST00000543669
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-017
ENSP00000437673
ENST00000539015
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 309 aa
35 kDa 		Yes 0
FHL1-018
ENSP00000486782
ENST00000628568
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-019
ENSP00000486631
ENST00000628443
A0A0D9SFI6 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 147 aa
16.8 kDa 		No 0
FHL1-020
ENSP00000487318
ENST00000627383
A0A0D9SGB2 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 138 aa
15.9 kDa 		No 0
FHL1-021
ENSP00000486436
ENST00000627578
A0A0D9SFB0 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 152 aa
17.4 kDa 		No 0
FHL1-022
ENSP00000487377
ENST00000630278
A0A0D9SGD1 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 78 aa
9.2 kDa 		No 0
FHL1-023
ENSP00000487360
ENST00000625935
A0A0D9SGC5 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 18 aa
2.2 kDa 		No 0
FHL1-024
ENSP00000444815
ENST00000535737
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-025
ENSP00000486134
ENST00000627812
A0A0D9SEY7 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 66 aa
7.9 kDa 		No 0
FHL1-026
ENSP00000487030
ENST00000628032
A0A0D9SFZ9 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 175 aa
19.9 kDa 		No 0
FHL1-027
ENSP00000487147
ENST00000628919
A0A0D9SG53 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 130 aa
15 kDa 		No 0
FHL1-031
ENSP00000477609
ENST00000618438
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 194 aa
22 kDa 		No 0
FHL1-201
ENSP00000377709
ENST00000394153
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 280 aa
31.9 kDa 		No 0
FHL1-202
ENSP00000377710
ENST00000394155
Q13642 [Direct mapping]
Four and a half LIM domains protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003254 [regulation of membrane depolarization]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0010972 [negative regulation of G2/M transition of mitotic cell cycle]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:1901016 [regulation of potassium ion transmembrane transporter activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 323 aa
36.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.