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EHD2

GENERAL INFORMATION

Gene name

 EHD2

Gene description

 EH-domain containing 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in adipocytes, pneumocytes, smooth muscle cells, endothelial cells, trophoblastic cells and a subset of germinal center cells.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 3 antibodies.
HPA047394 , HPA049890 , HPA049986
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EHD2 (HGNC Symbol)

Synonyms

 PAST2

Description

 EH-domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 47713343 - 47743134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000024422 (version 83.38)

Entrez gene

 30846

UniProt

 Q9NZN4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZN4

Antibodypedia

 EHD2 antibodies

PROTEIN BROWSER
EHD2-001
EHD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EHD2-001
ENSP00000263277
ENST00000263277
Q9NZN4 [Direct mapping]
EH domain-containing protein 2
A0A024R0S6 [Target identity:100%; Query identity:100%]
EH-domain containing 2, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006897 [endocytosis]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032456 [endocytic recycling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0097320 [membrane tubulation]
GO:1901741 [positive regulation of myoblast fusion]
GO:2001137 [positive regulation of endocytic recycling]
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 543 aa
61.2 kDa 		No 0
EHD2-002
ENSP00000439036
ENST00000538399
Q9NZN4 [Direct mapping]
EH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016787 [hydrolase activity]
GO:0019898 [extrinsic component of membrane]
GO:0032456 [endocytic recycling]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0097320 [membrane tubulation]
GO:1901741 [positive regulation of myoblast fusion]
GO:2001137 [positive regulation of endocytic recycling]
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 407 aa
46.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.