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Cancer tissues showed weak to moderate cytoplasmic staining. Occasional cases of urothelial cancers exhibited strong positivity. Many cases of malignant gliomas, lymphomas, melanomas, renal, ovarian and liver cancers were negative.
Cancer tissues showed moderate cytoplasmic and occasional nucleolar staining. Few cases of melanoma and colorectal cancers exhibited moderate to strong staining. Rare cases of thyroid, seminoma, breast, prostate and lung cancers displayed strong staining.
Cancer tissues showed a differentiated staining ranging from weak to strong cytoplasmic and nuclear staining positivity.
GENE INFORMATION
Gene name
WDR62 (HGNC Symbol)
Synonyms
C19orf14, DKFZP434J046, FLJ33298, MCPH2
Description
WD repeat domain 62 (HGNC Symbol)
Entrez gene summary
This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]