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EPB41L1

CANCER ATLAS

Gene description

 Erythrocyte membrane protein band 4.1-like 1

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054104
HPA056817

GENE INFORMATION

Gene name

 EPB41L1 (HGNC Symbol)

Synonyms

 4.1N, KIAA0338

Description

 Erythrocyte membrane protein band 4.1-like 1 (HGNC Symbol)

Entrez gene summary

 Erythrocyte membrane protein band 4.1 (EPB41) is a multifunctional protein that mediates interactions between the erythrocyte cytoskeleton and the overlying plasma membrane. The encoded protein binds and stabilizes D2 and D3 dopamine receptors at the neuronal plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 36091504 - 36232799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088367 (version 83.38)

Entrez gene

 2036

UniProt

 Q9H4G0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4G0

Antibodypedia

 EPB41L1 antibodies

PROTEIN BROWSER
«
EPB41L1-001
EPB41L1-002
EPB41L1-003
EPB41L1-004
EPB41L1-005
EPB41L1-006
EPB41L1-007
EPB41L1-008
EPB41L1-010
EPB41L1-011
EPB41L1-012
EPB41L1-013
EPB41L1-014
EPB41L1-015
EPB41L1-016
EPB41L1-201
EPB41L1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPB41L1-001
ENSP00000404341
ENST00000430276
Q4VXN0 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
 257 aa
29.5 kDa 		No 0
EPB41L1-002
ENSP00000396366
ENST00000447825
Q4VXN7 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.4 kDa 		No 0
EPB41L1-003
ENSP00000408877
ENST00000427533
Q4VXN8 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.2 kDa 		No 0
EPB41L1-004
ENSP00000413262
ENST00000452261
Q4VXN5 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
Show all
 188 aa
21 kDa 		No 0
EPB41L1-005
ENSP00000363056
ENST00000373945
Q4VXN1 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
 199 aa
23 kDa 		No 0
EPB41L1-006
ENSP00000406464
ENST00000451082
H7C2K6 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 268 aa
29.1 kDa 		No 0
EPB41L1-007
ENSP00000388281
ENST00000454226
X6RC15 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
GO:0008092 [cytoskeletal protein binding]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 197 aa
21.3 kDa 		No 0
EPB41L1-008
ENSP00000337168
ENST00000338074
Q9H4G0 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0097481 [neuronal postsynaptic density]
Show all
 881 aa
98.5 kDa 		No 0
EPB41L1-010
ENSP00000363061
ENST00000373950
Q9H4G0 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 772 aa
86.5 kDa 		No 0
EPB41L1-011
ENSP00000363052
ENST00000373941
A0A0C4DH22 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 880 aa
98.4 kDa 		No 0
EPB41L1-012
ENSP00000390262
ENST00000432603
H0Y482 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007016 [cytoskeletal anchoring at plasma membrane]
Show all
 119 aa
12.9 kDa 		No 0
EPB41L1-013
ENSP00000202028
ENST00000202028
Q9H4G0 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 779 aa
87.6 kDa 		No 0
EPB41L1-014
ENSP00000393106
ENST00000432589
Q4VXN2 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 37 aa
4.1 kDa 		No 0
EPB41L1-015
ENSP00000385244
ENST00000406771
Q4VXN6 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
Show all
 168 aa
18.7 kDa 		No 0
EPB41L1-016
ENSP00000487049
ENST00000628415
Q9H4G0 [Direct mapping]
Band 4.1-like protein 1
A0A0D9SG07 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 701 aa
78.8 kDa 		No 0
EPB41L1-201
ENSP00000363057
ENST00000373946
A0A0C4DH22 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 880 aa
98.4 kDa 		No 0
EPB41L1-202
ENSP00000399214
ENST00000441639
Q9H4G0 [Direct mapping]
Band 4.1-like protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007268 [synaptic transmission]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030866 [cortical actin cytoskeleton organization]
Show all
 779 aa
87.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.