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SLC15A1

GENERAL INFORMATION

Gene name

 SLC15A1

Gene description

 Solute carrier family 15 (oligopeptide transporter), member 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (small intestine, duodenum, gallbladder)
GTEx:Tissue enriched (small intestine)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 High luminal expression in small intestine and gall bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA002827
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, duodenum, gallbladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 SLC15A1 (HGNC Symbol)

Synonyms

 HPECT1, HPEPT1, PEPT1

Description

 Solute carrier family 15 (oligopeptide transporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

Chromosome

 13

Cytoband

Chromosome location (bp)

 98683801 - 98752654

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088386 (version 83.38)

Entrez gene

 6564

UniProt

 P46059 (UniProt - Evidence at transcript level)

neXtProt

 NX_P46059

Antibodypedia

 SLC15A1 antibodies

PROTEIN BROWSER
SLC15A1-001
SLC15A1-201
SLC15A1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC15A1-001
ENSP00000365686
ENST00000376503
P46059 [Direct mapping]
Solute carrier family 15 member 1
B2CQT6 [Target identity:100%; Query identity:100%]
Solute carrier family 15 oligopeptide transporter member 1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005427 [proton-dependent oligopeptide secondary active transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006857 [oligopeptide transport]
GO:0007586 [digestion]
GO:0015031 [protein transport]
GO:0015198 [oligopeptide transporter activity]
GO:0015333 [peptide:proton symporter activity]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035672 [oligopeptide transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
 708 aa
78.8 kDa 		No >9
SLC15A1-201
ENSP00000482440
ENST00000613008
O14496 [Direct mapping]
Solute carrier family 15 member 1; pH-sensing regulatory factor of peptide transporter
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0003674 [molecular_function]
GO:0005215 [transporter activity]
GO:0005575 [cellular_component]
GO:0006810 [transport]
GO:0006857 [oligopeptide transport]
GO:0015833 [peptide transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 208 aa
23.1 kDa 		No 7
SLC15A1-202
ENSP00000478051
ENST00000618992
A0A087WTQ1 [Direct mapping]
Solute carrier family 15 member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0006857 [oligopeptide transport]
GO:0015198 [oligopeptide transporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 706 aa
78.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.