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SLC8A3

GENERAL INFORMATION

Gene name

 SLC8A3

Gene description

 Solute carrier family 8 (sodium/calcium exchanger), member 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, skeletal muscle)
GTEx:Group enriched (skeletal muscle, hypothalamus, cerebral cortex, hippocampus, cerebellum, caudate)
FANTOM5:Tissue enhanced (skeletal muscle)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, hypothalamus, cerebral cortex, hippocampus, cerebellum, caudate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION

Gene name

 SLC8A3 (HGNC Symbol)

Synonyms

 NCX3

Description

 Solute carrier family 8 (sodium/calcium exchanger), member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]

Chromosome

 14

Cytoband

 q24.2

Chromosome location (bp)

 70044217 - 70189070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100678 (version 83.38)

Entrez gene

 6547

UniProt

 P57103 (UniProt - Evidence at protein level)

neXtProt

 NX_P57103

Antibodypedia

 SLC8A3 antibodies

PROTEIN BROWSER
SLC8A3-001
SLC8A3-003
SLC8A3-004
SLC8A3-005
SLC8A3-006
SLC8A3-007
SLC8A3-008
SLC8A3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC8A3-001
ENSP00000349392
ENST00000356921
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071456 [cellular response to hypoxia]
Show all
 921 aa
102.4 kDa 		Yes >9
SLC8A3-003
ENSP00000370669
ENST00000381269
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006816 [calcium ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0015368 [calcium:cation antiporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0021537 [telencephalon development]
GO:0030001 [metal ion transport]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0060402 [calcium ion transport into cytosol]
GO:0070588 [calcium ion transmembrane transport]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:1990034 [calcium ion export from cell]
GO:1990035 [calcium ion import into cell]
Show all
 927 aa
103 kDa 		Yes >9
SLC8A3-004
ENSP00000436688
ENST00000534137
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071456 [cellular response to hypoxia]
Show all
 924 aa
102.7 kDa 		Yes >9
SLC8A3-005
ENSP00000433531
ENST00000528359
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071456 [cellular response to hypoxia]
Show all
 925 aa
102.8 kDa 		Yes >9
SLC8A3-006
ENSP00000216568
ENST00000216568
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0016021 [integral component of membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071456 [cellular response to hypoxia]
Show all
 298 aa
32.7 kDa 		No 5
SLC8A3-007
ENSP00000377863
ENST00000394330
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0016021 [integral component of membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071456 [cellular response to hypoxia]
Show all
 284 aa
31.1 kDa 		No 5
SLC8A3-008
ENSP00000437103
ENST00000533541
F2Z391 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0006816 [calcium ion transport]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 210 aa
23.5 kDa 		No 2
SLC8A3-201
ENSP00000350560
ENST00000357887
P57103 [Direct mapping]
Sodium/calcium exchanger 3
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005432 [calcium:sodium antiporter activity]
GO:0005516 [calmodulin binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006851 [mitochondrial calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007154 [cell communication]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0014819 [regulation of skeletal muscle contraction]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031594 [neuromuscular junction]
GO:0035725 [sodium ion transmembrane transport]
GO:0042383 [sarcolemma]
GO:0042552 [myelination]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048709 [oligodendrocyte differentiation]
GO:0051560 [mitochondrial calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060291 [long-term synaptic potentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071456 [cellular response to hypoxia]
Show all
 925 aa
102.8 kDa 		Yes >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.