Tissue expression of ICAM4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ICAM4
Gene description	Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Protein class	Blood group antigen proteins CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung, epididymis)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	ICAM4 (HGNC Symbol)
Synonyms	CD242, LW
Description	Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) (HGNC Symbol)
Entrez gene summary	This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10286967 - 10288522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105371 (version 83.38)
Entrez gene	3386
UniProt	Q14773 (UniProt - Evidence at protein level)
neXtProt	NX_Q14773
Antibodypedia	ICAM4 antibodies

PROTEIN BROWSER

ICAM4-001	ICAM4-002	ICAM4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ICAM4-001 ENSP00000342114 ENST00000340992	Q14773 [Direct mapping] Intercellular adhesion molecule 4 U5U6P8 [Target identity:100%; Query identity:100%] Intercellular adhesion molecule 4 isoform 3; Intercellular adhesion molecule 4 isoform 3 anitgen LWa Show all	CD markers Blood group antigen proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0050776 [regulation of immune response] Show all	272 aa 29.6 kDa	Yes	0
ICAM4-002 ENSP00000370147 ENST00000380770	Q14773 [Direct mapping] Intercellular adhesion molecule 4 Show all	CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0050776 [regulation of immune response] Show all	271 aa 29.3 kDa	Yes	1
ICAM4-003 ENSP00000377320 ENST00000393717	Q14773 [Direct mapping] Intercellular adhesion molecule 4 Show all	CD markers Blood group antigen proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0050776 [regulation of immune response] Show all	237 aa 25.9 kDa	Yes	0